3-ethynyl-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)benzamide

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Chemical Name:3-ethynyl-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)benzamide
CAS No.:1571073-76-1
Molecular Formula:C₄₃H₄₅N₉O₄Si
Molecular Weight:779.974
Hs Code.:

Synonyms:3-ethynyl-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)benzamide

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Chemical Property of 3-ethynyl-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)benzamide

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Technology Process of 3-ethynyl-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)benzamide

There total 7 articles about 3-ethynyl-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 813449-46-6
1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazole-5-carboxylic acid

: 1562518-12-0
3-((4-((4-aminonaphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-ethynyl-N-(2-morpholinoethyl)benzamide

: 1571073-76-1
3-ethynyl-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)benzamide

Guidance literature:: 1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazole-5-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.333333h; Inert atmosphere;

3-((4-((4-aminonaphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-ethynyl-N-(2-morpholinoethyl)benzamide; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

Reference yield:

: 42237-85-4
3-amino-5-bromobenzoic acid

: 1571073-76-1
3-ethynyl-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane / 20 °C / Cooling with ice

2.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 80 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h

4.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 7 h / 55 - 60 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C / Inert atmosphere

6.2: 1 h / 100 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1525616-82-3
3-amino-5-bromo-N-(2-morpholinoethyl)benzamide

: 1571073-76-1
3-ethynyl-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 80 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h

3.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 7 h / 55 - 60 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C / Inert atmosphere

5.2: 1 h / 100 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;