2-amino-3-(4-chlorobenzoyl)isoquinolinium tosylate

Base Information

• Chemical Name: 2-amino-3-(4-chlorobenzoyl)isoquinolinium tosylate
• CAS No.: 82319-29-7
• Molecular Formula: C₇H₇O₃S*C₁₆H₁₂ClN₂O
• Molecular Weight: 454.934
• Mol file: 82319-29-7.mol

Synonyms:2-amino-3-(4-chlorobenzoyl)isoquinolinium tosylate

Chemical Property of 2-amino-3-(4-chlorobenzoyl)isoquinolinium tosylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-amino-3-(4-chlorobenzoyl)isoquinolinium tosylate

There total 3 articles about 2-amino-3-(4-chlorobenzoyl)isoquinolinium tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

O-tosylhydroxylamine (52913-14-1) + (4-chlorophenyl) (isoquinolin-3-yl)methanone (82319-66-2) → 2-amino-3-(4-chlorobenzoyl)isoquinolinium tosylate (82319-29-7)

Guidance literature:

In dichloromethane; for 5h; Ambient temperature;

DOI:10.1021/jo00274a020

Reference yield:

bromochlorobenzene (106-39-8) → 2-amino-3-(4-chlorobenzoyl)isoquinolinium tosylate (82319-29-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg / 1.) ether, 3 h, 2) 0 deg C, overnight

2: 79 percent / CH₂Cl₂ / 5 h / Ambient temperature

With magnesium; In dichloromethane;

DOI:10.1021/jo00274a020

Reference yield:

3-cyanoisoquinoline (26947-41-1) → 2-amino-3-(4-chlorobenzoyl)isoquinolinium tosylate (82319-29-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg / 1.) ether, 3 h, 2) 0 deg C, overnight

2: 79 percent / CH₂Cl₂ / 5 h / Ambient temperature

With magnesium; In dichloromethane;

DOI:10.1021/jo00274a020

upstream raw materials:

O-tosylhydroxylamine

(4-chlorophenyl) (isoquinolin-3-yl)methanone

bromochlorobenzene

3-cyanoisoquinoline

Downstream raw materials:

6,14-bis(4'-chlorobenzoyl)-8,8a,16,16a-tetrahydro<1,2,4,5>tetrazino<6,1-a:3,4-a'>diisoquinoline

Refernces

• 1、 -. "Condensed as-triazine derivatives and method of using the same". . . Retrieved 2008/06/13.