6-[1-(3-methoxyazetidin-1-yl)-ethyl]-3-phenyl-7H-imidazo[1,5-a]pyrazin-8-one

Base Information

Chemical Name:6-[1-(3-methoxyazetidin-1-yl)-ethyl]-3-phenyl-7H-imidazo[1,5-a]pyrazin-8-one
CAS No.:1430840-13-3
Molecular Formula:C₁₈H₂₀N₄O₂
Molecular Weight:324.382
Hs Code.:

Synonyms:6-[1-(3-methoxyazetidin-1-yl)-ethyl]-3-phenyl-7H-imidazo[1,5-a]pyrazin-8-one

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Chemical Property of 6-[1-(3-methoxyazetidin-1-yl)-ethyl]-3-phenyl-7H-imidazo[1,5-a]pyrazin-8-one

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Technology Process of 6-[1-(3-methoxyazetidin-1-yl)-ethyl]-3-phenyl-7H-imidazo[1,5-a]pyrazin-8-one

There total 11 articles about 6-[1-(3-methoxyazetidin-1-yl)-ethyl]-3-phenyl-7H-imidazo[1,5-a]pyrazin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 3-methoxyazetidine hydrochloride

: 1430841-42-1
6-acetyl-3-phenyl-7H-imidazo[1,5-a]pyrazin-8-one

: 1430840-13-3
6-[1-(3-methoxyazetidin-1-yl)-ethyl]-3-phenyl-7H-imidazo[1,5-a]pyrazin-8-one

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 25 ℃; for 144h;

Reference yield:

: 1430841-32-9
tert-butyl 5-(benzamidomethyl)-6-methoxypyrazin-2-ylcarbamate

: 1430840-13-3
6-[1-(3-methoxyazetidin-1-yl)-ethyl]-3-phenyl-7H-imidazo[1,5-a]pyrazin-8-one

Guidance literature:: Multi-step reaction with 7 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: copper(l) iodide; isopentyl nitrite; diiodomethane / tetrahydrofuran / 5 h / 75 °C / Inert atmosphere

3: trichlorophosphate / acetonitrile / 6 h / 85 °C / Inert atmosphere

4: triethylamine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 16 h / 90 °C

5: tetrahydrofuran / -78 - -30 °C

6: hydrogenchloride / methanol; water / 16 h / 60 °C

7: sodium cyanoborohydride; acetic acid / methanol / 144 h / 25 °C

With hydrogenchloride; copper(l) iodide; diiodomethane; palladium diacetate; sodium cyanoborohydride; acetic acid; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; trichlorophosphate; isopentyl nitrite; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1430841-34-1
N-((5-iodo-3-methoxypyrazin-2-yl)methyl)benzamide

: 1430840-13-3
6-[1-(3-methoxyazetidin-1-yl)-ethyl]-3-phenyl-7H-imidazo[1,5-a]pyrazin-8-one

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / acetonitrile / 6 h / 85 °C / Inert atmosphere

2: triethylamine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 16 h / 90 °C

3: tetrahydrofuran / -78 - -30 °C

4: hydrogenchloride / methanol; water / 16 h / 60 °C

5: sodium cyanoborohydride; acetic acid / methanol / 144 h / 25 °C

With hydrogenchloride; palladium diacetate; sodium cyanoborohydride; acetic acid; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trichlorophosphate; In tetrahydrofuran; methanol; water; toluene; acetonitrile;