ethyl 3-{4-fluoro-2-[3-(trifluoromethyl)benzyl]-1-benzothien-7-yl}benzoate

Base Information

Chemical Name:ethyl 3-{4-fluoro-2-[3-(trifluoromethyl)benzyl]-1-benzothien-7-yl}benzoate
CAS No.:1207970-98-6
Molecular Formula:C₂₅H₁₈F₄O₂S
Molecular Weight:458.476
Hs Code.:

Synonyms:ethyl 3-{4-fluoro-2-[3-(trifluoromethyl)benzyl]-1-benzothien-7-yl}benzoate

Suppliers and Price of ethyl 3-{4-fluoro-2-[3-(trifluoromethyl)benzyl]-1-benzothien-7-yl}benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 3-{4-fluoro-2-[3-(trifluoromethyl)benzyl]-1-benzothien-7-yl}benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 3-{4-fluoro-2-[3-(trifluoromethyl)benzyl]-1-benzothien-7-yl}benzoate

There total 14 articles about ethyl 3-{4-fluoro-2-[3-(trifluoromethyl)benzyl]-1-benzothien-7-yl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1207970-69-1
ethyl 3-[2-(bromomethyl)-4-fluoro-1-benzothiophen-7-yl]benzoate

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1207970-98-6
ethyl 3-{4-fluoro-2-[3-(trifluoromethyl)benzyl]-1-benzothien-7-yl}benzoate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 16h; Reflux;

Reference yield:

: 7-bromo-4-fluoro-2-[3-(trifluoromethyl)benzyl]-1-benzothiophene

: 4334-87-6
[3-(ethoxycarbonyl)phenyl]boronic acid

: 1207970-98-6
ethyl 3-{4-fluoro-2-[3-(trifluoromethyl)benzyl]-1-benzothien-7-yl}benzoate

Guidance literature:: With palladium diacetate; sodium carbonate; tris-(o-tolyl)phosphine; In 1,2-dimethoxyethane; water; at 80 ℃; for 2h; Inert atmosphere;
DOI:10.1055/s-0034-1378746

Reference yield:

: C₁₀H₁₀BrFO₂S

: 1207970-98-6
ethyl 3-{4-fluoro-2-[3-(trifluoromethyl)benzyl]-1-benzothien-7-yl}benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / N,N-dimethyl acetamide; water; ethanol / 1.5 h / Inert atmosphere

2: N,N-dimethyl-formamide; thionyl chloride / 1,2-dichloro-benzene / 1 h / 20 - 60 °C / Inert atmosphere

3: aluminum (III) chloride / 1,2-dichloro-benzene / 1.5 h / 0 - 10 °C / Inert atmosphere

4: piperidine / toluene / 3 h / 100 °C / Inert atmosphere

5: triethylsilane; methanesulfonic acid

6: palladium diacetate; tris-(o-tolyl)phosphine; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 80 °C / Inert atmosphere

With piperidine; triethylsilane; aluminum (III) chloride; thionyl chloride; methanesulfonic acid; palladium diacetate; sodium carbonate; N,N-dimethyl-formamide; tris-(o-tolyl)phosphine; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl acetamide; water; 1,2-dichloro-benzene; toluene; 3: |Friedel-Crafts Acylation / 4: |Knoevenagel Condensation / 6: |Suzuki-Miyaura Coupling;
DOI:10.1055/s-0034-1378746