(Z)-7-[(1R,2R,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(1E,5E)-4,4-difluoro-3-[(4-methoxyphenyl)methoxy]octa-1,5-dien-1-yl]-5-oxocyclopentyl]hept-5-enoic acid prop-2-yl ester

Base Information

Chemical Name:(Z)-7-[(1R,2R,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(1E,5E)-4,4-difluoro-3-[(4-methoxyphenyl)methoxy]octa-1,5-dien-1-yl]-5-oxocyclopentyl]hept-5-enoic acid prop-2-yl ester
CAS No.:1372609-25-0
Molecular Formula:C₃₇H₅₆F₂O₆Si
Molecular Weight:662.93
Hs Code.:

(Z)-7-[(1R,2R,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(1E,5E)-4,4-difluoro-3-[(4-methoxyphenyl)methoxy]octa-1,5-dien-1-yl]-5-oxocyclopentyl]hept-5-enoic acid prop-2-yl ester

Synonyms:(Z)-7-[(1R,2R,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(1E,5E)-4,4-difluoro-3-[(4-methoxyphenyl)methoxy]octa-1,5-dien-1-yl]-5-oxocyclopentyl]hept-5-enoic acid prop-2-yl ester

Suppliers and Price of (Z)-7-[(1R,2R,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(1E,5E)-4,4-difluoro-3-[(4-methoxyphenyl)methoxy]octa-1,5-dien-1-yl]-5-oxocyclopentyl]hept-5-enoic acid prop-2-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (Z)-7-[(1R,2R,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(1E,5E)-4,4-difluoro-3-[(4-methoxyphenyl)methoxy]octa-1,5-dien-1-yl]-5-oxocyclopentyl]hept-5-enoic acid prop-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (Z)-7-[(1R,2R,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(1E,5E)-4,4-difluoro-3-[(4-methoxyphenyl)methoxy]octa-1,5-dien-1-yl]-5-oxocyclopentyl]hept-5-enoic acid prop-2-yl ester

There total 3 articles about (Z)-7-[(1R,2R,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(1E,5E)-4,4-difluoro-3-[(4-methoxyphenyl)methoxy]octa-1,5-dien-1-yl]-5-oxocyclopentyl]hept-5-enoic acid prop-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 474944-36-0
(Z)-7-[(3R)-3-(tert-butyldimethylsilanyloxy)-5-oxo-cyclopent-1-enyl]hept-5-enoic acid isopropyl ester

: 1372609-23-8
((1E,5E)-3-(4-methoxy-benzyloxy)-4,4-difluoroocta-1,5-dienyl)tributylstannane

: 1372609-25-0
(Z)-7-[(1R,2R,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(1E,5E)-4,4-difluoro-3-[(4-methoxyphenyl)methoxy]octa-1,5-dien-1-yl]-5-oxocyclopentyl]hept-5-enoic acid prop-2-yl ester

Guidance literature:: ((1E,5E)-3-(4-methoxy-benzyloxy)-4,4-difluoroocta-1,5-dienyl)tributylstannane; With methyllithium; In tetrahydrofuran; formaldehyde diethyl acetal; at -70 - -60 ℃; Inert atmosphere;

With methyllithium; copper(l) cyanide; In tetrahydrofuran; formaldehyde diethyl acetal; at -50 - -40 ℃; for 0.5h; Inert atmosphere;

(Z)-7-[(3R)-3-(tert-butyldimethylsilanyloxy)-5-oxo-cyclopent-1-enyl]hept-5-enoic acid isopropyl ester; In tetrahydrofuran; formaldehyde diethyl acetal; at -60 - -50 ℃; Inert atmosphere;

Reference yield:

: 1346523-54-3
ethyl 2,2-difluorohex-3-enoate

: 1372609-25-0
(Z)-7-[(1R,2R,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(1E,5E)-4,4-difluoro-3-[(4-methoxyphenyl)methoxy]octa-1,5-dien-1-yl]-5-oxocyclopentyl]hept-5-enoic acid prop-2-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere

1.2: -78 - -60 °C / Inert atmosphere

1.3: -78 - 10 °C

2.1: sodium tetrahydroborate; methanol / -5 - 0 °C

2.2: -5 - 0 °C / pH 5 - 6

3.1: 2,2'-azobis(isobutyronitrile) / toluene / 80 - 85 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / -10 - 0 °C

4.2: -10 - 0 °C

5.1: methyllithium / formaldehyde diethyl acetal; tetrahydrofuran / -70 - -60 °C / Inert atmosphere

5.2: 0.5 h / -50 - -40 °C / Inert atmosphere

5.3: -60 - -50 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; n-butyllithium; 2,2'-azobis(isobutyronitrile); methyllithium; sodium hydride; In tetrahydrofuran; formaldehyde diethyl acetal; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: C₂₀H₃₈F₂OSn

: 2746-25-0
p-Methoxybenzyl bromide

: 1372609-25-0
(Z)-7-[(1R,2R,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(1E,5E)-4,4-difluoro-3-[(4-methoxyphenyl)methoxy]octa-1,5-dien-1-yl]-5-oxocyclopentyl]hept-5-enoic acid prop-2-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / -10 - 0 °C

1.2: -10 - 0 °C

2.1: methyllithium / tetrahydrofuran / -70 - -60 °C

2.2: 0.5 h / -10 - 0 °C / Inert atmosphere

2.3: -50 - -40 °C

With methyllithium; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;