N-[3,5-bis(trifluoromethyl)phenyl]-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine

Base Information

Chemical Name:N-[3,5-bis(trifluoromethyl)phenyl]-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine
CAS No.:1365802-85-2
Molecular Formula:C₂₄H₁₅F₆N₅
Molecular Weight:487.407
Hs Code.:

Synonyms:N-[3,5-bis(trifluoromethyl)phenyl]-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3,5-bis(trifluoromethyl)phenyl]-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine

Chemical Property:

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Technology Process of N-[3,5-bis(trifluoromethyl)phenyl]-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine

There total 7 articles about N-[3,5-bis(trifluoromethyl)phenyl]-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1365803-21-9
1-[4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)-2-fluorophenyl]ethanone

: 1365802-85-2
N-[3,5-bis(trifluoromethyl)phenyl]-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine

Guidance literature:: With hydrazine hydrate; In 1,4-dioxane; Reflux;

Reference yield:

: 328-74-5
3,5-Bis-(trifluoromethyl)aniline

: 1365802-85-2
N-[3,5-bis(trifluoromethyl)phenyl]-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / 1,4-dioxane; mineral oil / 60 °C

2: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 110 °C / microwave irradiation

3: hydrazine hydrate / 1,4-dioxane / Reflux

With potassium phosphate; hydrazine hydrate; sodium hydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; mineral oil;

Reference yield:

: 112704-79-7
2-fluoro-4-bromobenzoic acid

: 1365802-85-2
N-[3,5-bis(trifluoromethyl)phenyl]-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine

Guidance literature:: Multi-step reaction with 5 steps

1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: diethyl ether; tetrahydrofuran / 3 h / 0 - 20 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 80 °C

4: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 110 °C / microwave irradiation

5: hydrazine hydrate / 1,4-dioxane / Reflux

With dmap; potassium phosphate; hydrazine hydrate; potassium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water;