(E,E,7S)-methyl-8-<(2R,6S)-6-<(3R,4S,6R,7S,8S,9S,10S,11S)-8,10-di-tert-butylsilylenedioxy-4,6-((R)-para-methoxybenzylidenedioxy)-13-((2S,4R,6S)-2-methyl-4-methoxytetrahydropyran-6-yl)-2-oxo-3,7,9,11-tetramethyltridecan-1-yl>-5,6-dihydro-2H-pyran-2-yl>-.

Base Information

Chemical Name:(E,E,7S)-methyl-8-<(2R,6S)-6-<(3R,4S,6R,7S,8S,9S,10S,11S)-8,10-di-tert-butylsilylenedioxy-4,6-((R)-para-methoxybenzylidenedioxy)-13-((2S,4R,6S)-2-methyl-4-methoxytetrahydropyran-6-yl)-2-oxo-3,7,9,11-tetramethyltridecan-1-yl>-5,6-dihydro-2H-pyran-2-yl>-.
CAS No.:169131-28-6
Molecular Formula:C₆₁H₁₀₂O₁₂Si₂
Molecular Weight:1083.64
Hs Code.:

(E,E,7S)-methyl-8-<(2R,6S)-6-<(3R,4S,6R,7S,8S,9S,10S,11S)-8,10-di-tert-butylsilylenedioxy-4,6-((R)-para-methoxybenzylidenedioxy)-13-((2S,4R,6S)-2-methyl-4-methoxytetrahydropyran-6-yl)-2-oxo-3,7,9,11-tetramethyltridecan-1-yl>-5,6-dihydro-2H-pyran-2-yl>-.

Synonyms:(E,E,7S)-methyl-8-<(2R,6S)-6-<(3R,4S,6R,7S,8S,9S,10S,11S)-8,10-di-tert-butylsilylenedioxy-4,6-((R)-para-methoxybenzylidenedioxy)-13-((2S,4R,6S)-2-methyl-4-methoxytetrahydropyran-6-yl)-2-oxo-3,7,9,11-tetramethyltridecan-1-yl>-5,6-dihydro-2H-pyran-2-yl>-.

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Chemical Property of (E,E,7S)-methyl-8-<(2R,6S)-6-<(3R,4S,6R,7S,8S,9S,10S,11S)-8,10-di-tert-butylsilylenedioxy-4,6-((R)-para-methoxybenzylidenedioxy)-13-((2S,4R,6S)-2-methyl-4-methoxytetrahydropyran-6-yl)-2-oxo-3,7,9,11-tetramethyltridecan-1-yl>-5,6-dihydro-2H-pyran-2-yl>-.

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Technology Process of (E,E,7S)-methyl-8-<(2R,6S)-6-<(3R,4S,6R,7S,8S,9S,10S,11S)-8,10-di-tert-butylsilylenedioxy-4,6-((R)-para-methoxybenzylidenedioxy)-13-((2S,4R,6S)-2-methyl-4-methoxytetrahydropyran-6-yl)-2-oxo-3,7,9,11-tetramethyltridecan-1-yl>-5,6-dihydro-2H-pyran-2-yl>-.

There total 8 articles about (E,E,7S)-methyl-8-<(2R,6S)-6-<(3R,4S,6R,7S,8S,9S,10S,11S)-8,10-di-tert-butylsilylenedioxy-4,6-((R)-para-methoxybenzylidenedioxy)-13-((2S,4R,6S)-2-methyl-4-methoxytetrahydropyran-6-yl)-2-oxo-3,7,9,11-tetramethyltridecan-1-yl>-5,6-dihydro-2H-pyran-2-yl>-. which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 157117-36-7
(E,E,7S)-methyl-8-<(2R,6S)-6-<(2R,3R,4S,6R,7S,8S,9S,10S,11S)-8,10-di-tert-butylsilylenedioxy-2-hydroxy-4,6-((R)-para-methoxybenzylidenedioxy)-13-((2S,4R,6S)-2-methyl-4-methoxytetrahydropyran-6-yl)-3,7,9,11-tetramethyltridecan-1-yl>-5,6-dihydro-2H-...

: 169131-28-6
(E,E,7S)-methyl-8-<(2R,6S)-6-<(3R,4S,6R,7S,8S,9S,10S,11S)-8,10-di-tert-butylsilylenedioxy-4,6-((R)-para-methoxybenzylidenedioxy)-13-((2S,4R,6S)-2-methyl-4-methoxytetrahydropyran-6-yl)-2-oxo-3,7,9,11-tetramethyltridecan-1-yl>-5,6-dihydro-2H-pyran-2-yl>-.

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/0040-4020(95)00548-M

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 169131-28-6
(E,E,7S)-methyl-8-<(2R,6S)-6-<(3R,4S,6R,7S,8S,9S,10S,11S)-8,10-di-tert-butylsilylenedioxy-4,6-((R)-para-methoxybenzylidenedioxy)-13-((2S,4R,6S)-2-methyl-4-methoxytetrahydropyran-6-yl)-2-oxo-3,7,9,11-tetramethyltridecan-1-yl>-5,6-dihydro-2H-pyran-2-yl>-.

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) O₃, 2.) TfOH / 1.) CH₂Cl₂, MeOH, -78 deg C, 15 min, 2.) Et₂O, 20 deg C, 1 h

2: 1.) (c-C₆H₁₁)2BCl, Et₃N, 3.) H₂O₂

3: 93 percent / catecholborane / tetrahydrofuran / 23 h / -78 - 20 °C

4: 83 percent / DDQ, 4A molecular sieves / CH₂Cl₂ / 0.5 h / 20 °C

5: Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

With trifluorormethanesulfonic acid; 4 A molecular sieve; dicyclohexylboron chloride; dihydrogen peroxide; Dess-Martin periodane; ozone; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; benzo[1,3,2]dioxaborole; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00085a050

Reference yield:

: 142144-24-9
(2S,3S,4S,5S,6S)-2,4,6-trimethyl-8-((2S,4R,6S)-2-methyl-4-methoxytetrahydropyran-6-yl)-3,5-di-tert-butylsilylenedioxyoctanal

: 169131-28-6
(E,E,7S)-methyl-8-<(2R,6S)-6-<(3R,4S,6R,7S,8S,9S,10S,11S)-8,10-di-tert-butylsilylenedioxy-4,6-((R)-para-methoxybenzylidenedioxy)-13-((2S,4R,6S)-2-methyl-4-methoxytetrahydropyran-6-yl)-2-oxo-3,7,9,11-tetramethyltridecan-1-yl>-5,6-dihydro-2H-pyran-2-yl>-.

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / TiCl₄ / CH₂Cl₂ / 0.5 h / -90 °C

2: 1.) O₃, 2.) TfOH / 1.) CH₂Cl₂, MeOH, -78 deg C, 15 min, 2.) Et₂O, 20 deg C, 1 h

3: 1.) (c-C₆H₁₁)2BCl, Et₃N, 3.) H₂O₂

4: 93 percent / catecholborane / tetrahydrofuran / 23 h / -78 - 20 °C

5: 83 percent / DDQ, 4A molecular sieves / CH₂Cl₂ / 0.5 h / 20 °C

6: Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

With trifluorormethanesulfonic acid; 4 A molecular sieve; dicyclohexylboron chloride; dihydrogen peroxide; titanium tetrachloride; Dess-Martin periodane; ozone; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; benzo[1,3,2]dioxaborole; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00085a050