Chemical Property of (2E,10E,12E,16Z,18E)-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15,17-hexamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
Chemical Property:
- Vapor Pressure:2.96E-26mmHg at 25°C
- Boiling Point:754.2°C at 760 mmHg
- Flash Point:236.5°C
- PSA：121.13000
- Density:1.118g/cm3
- LogP:5.36700
- XLogP3:6.2
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:15
- Exact Mass:542.32435380
- Heavy Atom Count:39
- Complexity:1030
- Purity/Quality:
-
>95% by HPLC *data from raw suppliers
Kazusamycin B *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1C=CC(=O)OC1C=CC(=CC(C)CC=CC(=CC(CO)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C
- Isomeric SMILES:CC1C=CC(=O)OC1/C=C/C(=C\C(C)C/C=C/C(=C/C(CO)C(=O)C(C)C(C(C)C/C(=C/C(=O)O)/C)O)/C)/C
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Uses
Kazusamycin B is a minor component of the leptomycin complex produced by some Streptomyces sp.. It is an hydroxylated analogue of leptomycin A, a nuclear export inhibitor. Kazusamycin B displays potent antitumour activity against L1210 and human colon adenocarcinoma, and in vivo activity against P388 lymphocytic leukemia in mice. Kazusamycin B also possesses strong antibacterial and antifungal activity. Kazusamycin B is a minor component of the leptomycin complex that displays anti-bacterial & anti-fungal activity.
