*,R^*)>-3-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester

Base Information

• Chemical Name: *,R^*)>-3-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester
• CAS No.: 126110-98-3
• Molecular Formula: C₁₉H₂₆N₂O₇
• Molecular Weight: 394.425

Synonyms:*,R^*)>-3-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester

Chemical Property of *,R^*)>-3-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of *,R^*)>-3-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester

There total 2 articles about *,R^*)>-3-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

*,R*)>-3-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester (126111-27-1) → *,R*)>-3-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester (126110-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 N LiOH / dioxane / 16 h / Ambient temperature

2: tetrahydrofuran; diethyl ether / 0 °C

With lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether;

DOI:10.1021/jm00167a028

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + (S)-3-((S)-6-Benzyloxycarbonylamino-2-hydroxy-hexanoyl)-oxazolidine-4-carboxylic acid → *,R*)>-3-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester (126110-98-3)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 ℃; Yield given;

DOI:10.1021/jm00167a028

Reference yield:

*,R*)>-3-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester (126110-98-3) → (S)-3-{(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-oxazolidine-4-carboxylic acid (126110-45-0)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature

2: NaIO₄ / dioxane; H₂O / 16 h / Ambient temperature

3: 82 percent / H₂ / 20percent Pd(OH)2/C / methanol / 2 h

With dmap; sodium periodate; hydrogen; dicyclohexyl-carbodiimide; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water;

DOI:10.1021/jm00167a028

upstream raw materials:

diazomethane

*,R^*)>-3-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-4-oxazolidinecarboxylic acid methyl ester

Downstream raw materials:

(S)-3-{(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-oxazolidine-4-carboxylic acid

(S)-3-{(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-oxazolidine-4-carboxylic acid methyl ester

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