methyl (1aR,7bS)-5-[2-(1-ethylpiperidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Base Information

Chemical Name:methyl (1aR,7bS)-5-[2-(1-ethylpiperidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate
CAS No.:1412979-37-3
Molecular Formula:C₂₆H₃₁FN₂O₅S
Molecular Weight:502.607
Hs Code.:

Synonyms:methyl (1aR,7bS)-5-[2-(1-ethylpiperidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

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Chemical Property of methyl (1aR,7bS)-5-[2-(1-ethylpiperidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

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Technology Process of methyl (1aR,7bS)-5-[2-(1-ethylpiperidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

There total 14 articles about methyl (1aR,7bS)-5-[2-(1-ethylpiperidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1412976-22-7
methyl (1aR,7bS)-5-amino-1,1 a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1412979-39-5
2-(1-ethylpiperidin-3-ylmethyl)-4-fluorobenzenesulfonyl chloride

: 1412979-37-3
methyl (1aR,7bS)-5-[2-(1-ethylpiperidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: methyl (1aR,7bS)-5-amino-1,1 a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate; 2-(1-ethylpiperidin-3-ylmethyl)-4-fluorobenzenesulfonyl chloride; In pyridine; dichloromethane; at 20 ℃; for 4h;

With ammonia; In methanol; dichloromethane;

Reference yield:

: 1412979-45-3
1-{3-[1-(3-fluorophenyl)methylidene]piperidin-1-yl}ethanone

: 1412979-37-3
methyl (1aR,7bS)-5-[2-(1-ethylpiperidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / 20% palladium hydroxide-activated charcoal / ethyl acetate; industrial methylated spirit / 21.5 h / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

3: chlorosulfonic acid / 1,2-dichloro-ethane / 2 h / 20 °C

4: dichloromethane; pyridine / 4 h / 20 °C

With chlorosulfonic acid; lithium aluminium tetrahydride; hydrogen; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; pyridine; industrial methylated spirit; dichloromethane; ethyl acetate; 1,2-dichloro-ethane;

Reference yield:

: 1412979-41-9
1-ethyl-3-(3-fluorobenzyl)piperidine

: 1412979-37-3
methyl (1aR,7bS)-5-[2-(1-ethylpiperidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: chlorosulfonic acid / 1,2-dichloro-ethane / 2 h / 20 °C

2: dichloromethane; pyridine / 4 h / 20 °C

With chlorosulfonic acid; In pyridine; dichloromethane; 1,2-dichloro-ethane;