7-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-3,4-dihydronaphthalen-1(2H)-one

Base Information

Chemical Name:7-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-3,4-dihydronaphthalen-1(2H)-one
CAS No.:1176326-75-2
Molecular Formula:C₂₇H₃₄BrNO₃
Molecular Weight:500.476
Hs Code.:

Synonyms:7-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-3,4-dihydronaphthalen-1(2H)-one

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Chemical Property of 7-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-3,4-dihydronaphthalen-1(2H)-one

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Technology Process of 7-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-3,4-dihydronaphthalen-1(2H)-one

There total 8 articles about 7-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-3,4-dihydronaphthalen-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1176327-20-0
4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidine hydrochloride

: 1176328-85-0
2-(8-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)ethyl 4-methylbenzenesulfonate

: 1176326-75-2
7-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-3,4-dihydronaphthalen-1(2H)-one

Guidance literature:: With potassium carbonate; In acetonitrile; for 5h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2018.02.008

Reference yield:

: 10031-93-3
ethyl 4-phenylbutyrate

: 1176326-75-2
7-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-3,4-dihydronaphthalen-1(2H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: aluminum (III) chloride / dichloromethane / 1.33 h / 20 °C / Inert atmosphere

2: morpholine; sulfur / 2.5 h / Inert atmosphere; Reflux

3: polyphosphoric acid / 2 h / 80 °C / Inert atmosphere

4: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 65 °C / Inert atmosphere

5: manganese(IV) oxide / dichloromethane / 21 h / 20 °C / Inert atmosphere

6: trimethylamine hydrochloride; triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

7: potassium carbonate / acetonitrile / 5 h / Inert atmosphere; Reflux

With morpholine; sulfur; manganese(IV) oxide; aluminum (III) chloride; lithium aluminium tetrahydride; trimethylamine hydrochloride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile; 2: |Willgerodt-Kindler Rearrangement;
DOI:10.1016/j.bmc.2018.02.008

Reference yield:

: 1-tetralone-7-acetic acid

: 1176326-75-2
7-(2-{4-[4-bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-3,4-dihydronaphthalen-1(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 65 °C / Inert atmosphere

2: manganese(IV) oxide / dichloromethane / 21 h / 20 °C / Inert atmosphere

3: trimethylamine hydrochloride; triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

4: potassium carbonate / acetonitrile / 5 h / Inert atmosphere; Reflux

With manganese(IV) oxide; lithium aluminium tetrahydride; trimethylamine hydrochloride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2018.02.008