N,N'-[(1R,2S)-1-(4-methoxyphenyl)-3-methylbutane-1,2-diyl]bis(trifluoroacetamide)

Base Information

Chemical Name:N,N'-[(1R,2S)-1-(4-methoxyphenyl)-3-methylbutane-1,2-diyl]bis(trifluoroacetamide)
CAS No.:1421479-39-1
Molecular Formula:C₁₆H₁₈F₆N₂O₃
Molecular Weight:400.321
Hs Code.:

Synonyms:N,N'-[(1R,2S)-1-(4-methoxyphenyl)-3-methylbutane-1,2-diyl]bis(trifluoroacetamide)

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Chemical Property of N,N'-[(1R,2S)-1-(4-methoxyphenyl)-3-methylbutane-1,2-diyl]bis(trifluoroacetamide)

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Technology Process of N,N'-[(1R,2S)-1-(4-methoxyphenyl)-3-methylbutane-1,2-diyl]bis(trifluoroacetamide)

There total 6 articles about N,N'-[(1R,2S)-1-(4-methoxyphenyl)-3-methylbutane-1,2-diyl]bis(trifluoroacetamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1421479-37-9
(1R,2S)-1-(4-methoxyphenyl)-3-methylbutane-1,2-diamine

: 407-25-0
trifluoroacetic anhydride

: 1421479-39-1
N,N'-[(1R,2S)-1-(4-methoxyphenyl)-3-methylbutane-1,2-diyl]bis(trifluoroacetamide)

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol3034753

Reference yield:

: 1421479-11-9
4-isopropyl-3-(4-methoxyphenyl)-1,2,5-thiadiazole-1,1-dioxide

: 1421479-39-1
N,N'-[(1R,2S)-1-(4-methoxyphenyl)-3-methylbutane-1,2-diyl]bis(trifluoroacetamide)

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); formic acid / acetonitrile / 48 h / -15 °C / Inert atmosphere

2: lithium borohydride / diethyl ether; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: hydrazine hydrate / 14 h / 110 °C

4: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

With lithium borohydride; [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); formic acid; hydrazine hydrate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/ol3034753

Reference yield:

: 1421479-21-1
(S)-4-isopropyl-3-(4-methoxyphenyl)-4,5-dihydro-1,2,5-thiadiazoline-1,1-dioxide

: 1421479-39-1
N,N'-[(1R,2S)-1-(4-methoxyphenyl)-3-methylbutane-1,2-diyl]bis(trifluoroacetamide)

Guidance literature:: Multi-step reaction with 3 steps

1: lithium borohydride / diethyl ether; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: hydrazine hydrate / 14 h / 110 °C

3: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

With lithium borohydride; hydrazine hydrate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ol3034753