(3R,5R,6S,7S)-7-(Benzyloxymethyl)-6-(4-fluorophenyl)-3-(-2-methoxy-5-(trifluoromethyl)phenyl)-1-oxaspiro[4.4]nonane

Base Information

Chemical Name:(3R,5R,6S,7S)-7-(Benzyloxymethyl)-6-(4-fluorophenyl)-3-(-2-methoxy-5-(trifluoromethyl)phenyl)-1-oxaspiro[4.4]nonane
CAS No.:207110-84-7
Molecular Formula:C₃₀H₃₀F₄O₃
Molecular Weight:514.56
Hs Code.:

Synonyms:(3R,5R,6S,7S)-7-(Benzyloxymethyl)-6-(4-fluorophenyl)-3-(-2-methoxy-5-(trifluoromethyl)phenyl)-1-oxaspiro[4.4]nonane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,5R,6S,7S)-7-(Benzyloxymethyl)-6-(4-fluorophenyl)-3-(-2-methoxy-5-(trifluoromethyl)phenyl)-1-oxaspiro[4.4]nonane

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Technology Process of (3R,5R,6S,7S)-7-(Benzyloxymethyl)-6-(4-fluorophenyl)-3-(-2-methoxy-5-(trifluoromethyl)phenyl)-1-oxaspiro[4.4]nonane

There total 3 articles about (3R,5R,6S,7S)-7-(Benzyloxymethyl)-6-(4-fluorophenyl)-3-(-2-methoxy-5-(trifluoromethyl)phenyl)-1-oxaspiro[4.4]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3S,5R,6S,7S)-7-(benzyloxymethyl)-6-(4-fluorophenyl)-3-hydroxy-3-(2-methoxy-5-(trifluoromethyl)phenyl)-1-oxaspiro[4.4]nonane

: 207110-84-7
(3R,5R,6S,7S)-7-(Benzyloxymethyl)-6-(4-fluorophenyl)-3-(-2-methoxy-5-(trifluoromethyl)phenyl)-1-oxaspiro[4.4]nonane

Guidance literature:: With triethylsilane; In ethyl acetate; toluene; trifluoroacetic acid;

Reference yield:

: 402-10-8
2-bromo-1-methoxy-4-(trifluoromethyl)benzene

: 207110-84-7
(3R,5R,6S,7S)-7-(Benzyloxymethyl)-6-(4-fluorophenyl)-3-(-2-methoxy-5-(trifluoromethyl)phenyl)-1-oxaspiro[4.4]nonane

Guidance literature:: Multi-step reaction with 2 steps

1: tert.-butyl lithium / tetrahydrofuran; hexane; water; ethyl acetate; toluene

2: triethylsilane / ethyl acetate; toluene; trifluoroacetic acid

With triethylsilane; tert.-butyl lithium; In tetrahydrofuran; hexane; water; ethyl acetate; toluene; trifluoroacetic acid;

Reference yield:

: (5R,6S,7S)-7-(benzyloxymethyl)-6-(4-fluorophenyl)-1-oxaspiro[4.4]nonane-3-one

: 207110-84-7
(3R,5R,6S,7S)-7-(Benzyloxymethyl)-6-(4-fluorophenyl)-3-(-2-methoxy-5-(trifluoromethyl)phenyl)-1-oxaspiro[4.4]nonane

Guidance literature:: Multi-step reaction with 2 steps

1: tert.-butyl lithium / tetrahydrofuran; hexane; water; ethyl acetate; toluene

2: triethylsilane / ethyl acetate; toluene; trifluoroacetic acid

With triethylsilane; tert.-butyl lithium; In tetrahydrofuran; hexane; water; ethyl acetate; toluene; trifluoroacetic acid;