6-(3 - allylphenoxy)-5S-amino-4S-hydoxy-2R-methoxy-hexanoic acid (4-fluorophenyl)amide

Base Information

Chemical Name:6-(3 - allylphenoxy)-5S-amino-4S-hydoxy-2R-methoxy-hexanoic acid (4-fluorophenyl)amide
CAS No.:1079398-72-3
Molecular Formula:C₂₂H₂₇FN₂O₄
Molecular Weight:402.466
Hs Code.:

Synonyms:6-(3 - allylphenoxy)-5S-amino-4S-hydoxy-2R-methoxy-hexanoic acid (4-fluorophenyl)amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(3 - allylphenoxy)-5S-amino-4S-hydoxy-2R-methoxy-hexanoic acid (4-fluorophenyl)amide

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Technology Process of 6-(3 - allylphenoxy)-5S-amino-4S-hydoxy-2R-methoxy-hexanoic acid (4-fluorophenyl)amide

There total 12 articles about 6-(3 - allylphenoxy)-5S-amino-4S-hydoxy-2R-methoxy-hexanoic acid (4-fluorophenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₅FN₄O₄

: 1079398-72-3
6-(3 - allylphenoxy)-5S-amino-4S-hydoxy-2R-methoxy-hexanoic acid (4-fluorophenyl)amide

Guidance literature:: With triphenylphosphine; In methanol; water; at 20 ℃;

Reference yield:

: 2398-37-0
3-methoxyphenyl bromide

: 1079398-72-3
6-(3 - allylphenoxy)-5S-amino-4S-hydoxy-2R-methoxy-hexanoic acid (4-fluorophenyl)amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: magnesium / iodine / tetrahydrofuran / 4 h / Heating / reflux

2.1: boron tribromide / dichloromethane / 3 h / 0 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 20 - 110 °C

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.25 h / -15 °C

4.2: 12.5 h / -15 - 20 °C

5.1: hydrogenchloride / 3 h / 0 - 20 °C

6.1: silver(l) oxide / N,N-dimethyl-formamide / 14 h / 20 °C

7.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 - 70 °C

8.1: triphenylphosphine / methanol; water / 20 °C

With 2-hydroxypyridin; hydrogenchloride; di-isopropyl azodicarboxylate; boron tribromide; potassium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; triphenylphosphine; silver(l) oxide; iodine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 79233-85-5
O-[1,2:5,6-di-O-isopropylidene-α-D-glucofuranosyl] 1H-imidazole-1-carbothioate

: 1079398-72-3
6-(3 - allylphenoxy)-5S-amino-4S-hydoxy-2R-methoxy-hexanoic acid (4-fluorophenyl)amide

Guidance literature:: Multi-step reaction with 9 steps

1.1: tri-n-butyl-tin hydride / 2,2'-azobis(isobutyronitrile) / toluene / 6.5 h / Heating / reflux

2.1: water; acetic acid / 10 h / 0 - 20 °C

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / chloroform / 10 h / Heating / reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 20 - 110 °C

5.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.25 h / -15 °C

5.2: 12.5 h / -15 - 20 °C

6.1: hydrogenchloride / 3 h / 0 - 20 °C

7.1: silver(l) oxide / N,N-dimethyl-formamide / 14 h / 20 °C

8.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 - 70 °C

9.1: triphenylphosphine / methanol; water / 20 °C

With 2-hydroxypyridin; hydrogenchloride; di-isopropyl azodicarboxylate; water; tri-n-butyl-tin hydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; silver(l) oxide; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;