2-[3-(4-chloro-phenyl)-5-methyl-pyrazol-1-yl]-4-(5-fluoro-pyridin-2-ylmethyl)cyclopentane-1,3-dione

Base Information

Chemical Name:2-[3-(4-chloro-phenyl)-5-methyl-pyrazol-1-yl]-4-(5-fluoro-pyridin-2-ylmethyl)cyclopentane-1,3-dione
CAS No.:1262511-72-7
Molecular Formula:C₂₁H₁₇ClFN₃O₂
Molecular Weight:397.836
Hs Code.:

Synonyms:2-[3-(4-chloro-phenyl)-5-methyl-pyrazol-1-yl]-4-(5-fluoro-pyridin-2-ylmethyl)cyclopentane-1,3-dione

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Chemical Property of 2-[3-(4-chloro-phenyl)-5-methyl-pyrazol-1-yl]-4-(5-fluoro-pyridin-2-ylmethyl)cyclopentane-1,3-dione

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Technology Process of 2-[3-(4-chloro-phenyl)-5-methyl-pyrazol-1-yl]-4-(5-fluoro-pyridin-2-ylmethyl)cyclopentane-1,3-dione

There total 8 articles about 2-[3-(4-chloro-phenyl)-5-methyl-pyrazol-1-yl]-4-(5-fluoro-pyridin-2-ylmethyl)cyclopentane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262511-67-0
2-[3-(4-chloro-phenyl)-5-methyl-pyrazol-1-yl]-4-[1-(5-fluoro-pyridin-2-yl)-meth-(Z)-ylidene]cyclopentane-1,3-dione

: 1262511-72-7
2-[3-(4-chloro-phenyl)-5-methyl-pyrazol-1-yl]-4-(5-fluoro-pyridin-2-ylmethyl)cyclopentane-1,3-dione

Guidance literature:: With hydrogen; 5%-palladium/activated carbon; In methanol; for 6h; under 1125.11 Torr;

Reference yield:

: 17629-27-5
3-(4-chlorophenyl)-5-methylpyrazole

: 1262511-72-7
2-[3-(4-chloro-phenyl)-5-methyl-pyrazol-1-yl]-4-(5-fluoro-pyridin-2-ylmethyl)cyclopentane-1,3-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 200 °C / microwave irradiation

3.1: potassium carbonate / acetone / 3 h / 60 °C

4.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.5 h / -78 °C / Inert atmosphere

4.2: 1 h / -78 - 20 °C

5.1: hydrogenchloride; water / acetone / 1 h / 120 °C / microwave irradiation

6.1: hydrogen / 5%-palladium/activated carbon / methanol / 6 h / 1125.11 Torr

With hydrogenchloride; water; hydrogen; sodium hydride; potassium carbonate; lithium diisopropyl amide; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; n-heptane; ethylbenzene; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 1262512-19-5
5-[3-(4-chloro-phenyl)-5-methyl-pyrazol-1-yl]-4-oxo-pentanoic acid methyl ester

: 1262511-72-7
2-[3-(4-chloro-phenyl)-5-methyl-pyrazol-1-yl]-4-(5-fluoro-pyridin-2-ylmethyl)cyclopentane-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 200 °C / microwave irradiation

2.1: potassium carbonate / acetone / 3 h / 60 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.5 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 - 20 °C

4.1: hydrogenchloride; water / acetone / 1 h / 120 °C / microwave irradiation

5.1: hydrogen / 5%-palladium/activated carbon / methanol / 6 h / 1125.11 Torr

With hydrogenchloride; water; hydrogen; potassium carbonate; lithium diisopropyl amide; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; n-heptane; ethylbenzene; N,N-dimethyl-formamide; acetone;