11-ethyl-16-fluoroestradiol

Base Information

Chemical Name:11-ethyl-16-fluoroestradiol
CAS No.:129000-39-1
Molecular Formula:C₂₀H₂₇FO₂
Molecular Weight:318.432
Hs Code.:
Mol file:129000-39-1.mol

Synonyms:(8S,9S,11S,13S,14S,16R,17R)-11-Ethyl-16-fluoro-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol;11β-ethyl-16α-fluoroestra-1,3,5(10)-triene-3,17β-diol;

Suppliers and Price of 11-ethyl-16-fluoroestradiol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 11-ethyl-16-fluoroestradiol

Chemical Property:

Vapor Pressure:1.39E-09mmHg at 25°C
Boiling Point:468.6°C at 760 mmHg
Flash Point:237.2°C
PSA：40.46000
Density:1.19g/cm³
LogP:4.19330

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 11-ethyl-16-fluoroestradiol

There total 8 articles about 11-ethyl-16-fluoroestradiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 129000-53-9
11β-ethyl-16α-fluoro-3-<<(trifluoromethyl)sulfonyl>oxy>estra-1,3,5(10)-trien-17-one

: 129000-56-2
11β-ethyl-16α-fluoroestra-1,3,5(10)-triene-3,17α-diol

: 129000-39-1
11β-ethyl-16α-fluoroestra-1,3,5(10)-triene-3,17β-diol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; 1.) -78 deg C, 10 min, 2.) from -78 deg C to RT, 10 min;
DOI:10.1021/jm00174a009

Reference yield:

: 67020-41-1
(8S,13S,14S)-11-Ethyl-3-methoxy-13-methyl-6,7,8,12,13,14,15,16-octahydro-cyclopenta[a]phenanthren-17-one

: 129000-39-1
11β-ethyl-16α-fluoroestra-1,3,5(10)-triene-3,17β-diol

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) H₂, 2.) BF₃*S(CH₃)2 / 1.) 5percent Pd/C / 1.) ethyl acetate, methanol, 1 atm, 31 h, 2.) CH₂Cl₂, from 0 deg C to RT, 24 h

2: 95 percent / 2,6-lutidine / CH₂Cl₂ / 0.33 h / 0 °C

3: 40 percent / p-toluenesulfonic acid / 1.) a.) reflux, 4 h, b.) RT, 11 h, 2.) reflux, 8 h

4: 60 percent / acetonitrile; CH₂Cl₂ / 12 h / Ambient temperature

5: 74 percent / 10percent aq. EtOH / tetrahydrofuran / 12 h / Ambient temperature

6: 72 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

7: 57 percent / nBu₄NF / tetrahydrofuran / 0.5 h / Ambient temperature

8: 23 percent / LiAlH₄ / diethyl ether / 1.) -78 deg C, 10 min, 2.) from -78 deg C to RT, 10 min

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; boron dimethyl-trifluoro sulphide; ethanol; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jm00174a009

Reference yield:

: 64109-55-3
11β-ethyl-3-hydroxyestra-1,3,5(10)-trien-17-one

: 129000-39-1
11β-ethyl-16α-fluoroestra-1,3,5(10)-triene-3,17β-diol

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 0.33 h / 0 °C

2: 40 percent / p-toluenesulfonic acid / 1.) a.) reflux, 4 h, b.) RT, 11 h, 2.) reflux, 8 h

3: 60 percent / acetonitrile; CH₂Cl₂ / 12 h / Ambient temperature

4: 74 percent / 10percent aq. EtOH / tetrahydrofuran / 12 h / Ambient temperature

5: 72 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

6: 57 percent / nBu₄NF / tetrahydrofuran / 0.5 h / Ambient temperature

7: 23 percent / LiAlH₄ / diethyl ether / 1.) -78 deg C, 10 min, 2.) from -78 deg C to RT, 10 min

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; ethanol; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jm00174a009