Chemical Property of Helenalin
Chemical Property:
- Vapor Pressure:6.18E-11mmHg at 25°C
- Melting Point:167-168oC
- Refractive Index:1.4300 (estimate)
- Boiling Point:473°C at 760 mmHg
- PKA:13.29±0.60(Predicted)
- Flash Point:179.9°C
- PSA：63.60000
- Density:1.25g/cm3
- LogP:1.24630
- Storage Temp.:-20°
- Solubility.:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml).
- XLogP3:1.4
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:0
- Exact Mass:262.12050905
- Heavy Atom Count:19
- Complexity:506
- Purity/Quality:
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99% *data from raw suppliers
Helenalin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Chemical Classes:Biological Agents -> Plant Toxins
- Canonical SMILES:CC1CC2C(C(C3(C1C=CC3=O)C)O)C(=C)C(=O)O2
- Isomeric SMILES:C[C@@H]1C[C@@H]2[C@H]([C@@H]([C@]3([C@H]1C=CC3=O)C)O)C(=C)C(=O)O2
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Description
Helenalin (6754-13-8) is a novel sesquiterpene lactone which inhibits NFκB1?and displays potent anti-inflammatory activity2. It suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms.3 Helenalin also inhibits telomerase and this activity may be partially responsible for its anti-tumor effects.4
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Uses
Helenalin is a highly toxic compound, with hepatic and lymphatic tissues particularly vulnerable to its effects. It is believed to be responsible for the toxicity and skin irritation associated with Arnica. If enough of the plant is ingested, the helenalin produces severe gastroenteritis and internal bleeding of the digestive tract.
