(3aS,6R,6aR)-1,3,5-tribenzyl-6-hydroxytetrahydro-4H-pyrrolo[3,4-d]imidazole-2,4(1H)-dione

Base Information

Chemical Name:(3aS,6R,6aR)-1,3,5-tribenzyl-6-hydroxytetrahydro-4H-pyrrolo[3,4-d]imidazole-2,4(1H)-dione
CAS No.:634188-84-4
Molecular Formula:C₂₆H₂₅N₃O₃
Molecular Weight:427.503
Hs Code.:

Synonyms:(3aS,6R,6aR)-1,3,5-tribenzyl-6-hydroxytetrahydro-4H-pyrrolo[3,4-d]imidazole-2,4(1H)-dione

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Chemical Property of (3aS,6R,6aR)-1,3,5-tribenzyl-6-hydroxytetrahydro-4H-pyrrolo[3,4-d]imidazole-2,4(1H)-dione

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Technology Process of (3aS,6R,6aR)-1,3,5-tribenzyl-6-hydroxytetrahydro-4H-pyrrolo[3,4-d]imidazole-2,4(1H)-dione

There total 5 articles about (3aS,6R,6aR)-1,3,5-tribenzyl-6-hydroxytetrahydro-4H-pyrrolo[3,4-d]imidazole-2,4(1H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 26511-17-1
1,3,5-tribenzyl-2,4,6-trioxopyrrolo<3,4-d>imidazoline

: 634188-84-4
(3aS,6R,6aR)-1,3,5-tribenzyl-6-hydroxytetrahydro-4H-pyrrolo[3,4-d]imidazole-2,4(1H)-dione

Guidance literature:: With dimethylsulfide borane complex; polymer-supported-C₆H₄-4-SO₂-[(S)-2-CPh₂OH-pyrrolidin-1-yl]; In tetrahydrofuran; for 6h; Heating;
DOI:10.1055/s-2003-41051

Reference yield:

: 51591-75-4,634188-82-2
cis-1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid

: 634188-84-4
(3aS,6R,6aR)-1,3,5-tribenzyl-6-hydroxytetrahydro-4H-pyrrolo[3,4-d]imidazole-2,4(1H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / Ac₂O / xylene / 13 h / Heating

2: 90 percent / toluene / 5 h / Heating

3: 82 percent / BF₃*Et₂O; NaH; chiral polymer-supported oxazaborolidine / tetrahydrofuran / 3 h / Heating

With chiral polymer-supported oxazaborolidine; boron trifluoride diethyl etherate; acetic anhydride; sodium hydride; In tetrahydrofuran; toluene; xylene;
DOI:10.1248/cpb.53.743

Reference yield:

: 100-46-9
benzylamine

: 634188-84-4
(3aS,6R,6aR)-1,3,5-tribenzyl-6-hydroxytetrahydro-4H-pyrrolo[3,4-d]imidazole-2,4(1H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / pyridine / xylene / 8 h / Heating

2: 85 percent / LiH; (1S,2S)-1-(4-NO₂C₆H₄)-2-NH₂-3-(triphenylmethoxy)propan-1-ol; BF₃*Et₂O / tetrahydrofuran / Heating

With pyridine; boron trifluoride diethyl etherate; lithium hydride; (1S,2S)-2-amino-1-(4-nitrophenyl)-3-(triphenylmethoxy)propan-1-ol; In tetrahydrofuran; xylene;
DOI:10.1016/j.tetasy.2003.08.034