1-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11-dioxo-14,17,20-trioxa-2,8 ,10-triazadocos-9-en-22-yl)-4-((E)-2-(1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)ethenyl)-2,6-dimethylpyridinium hydrotrifluoroacetate trifluoroacetate

Base Information

Chemical Name:1-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11-dioxo-14,17,20-trioxa-2,8 ,10-triazadocos-9-en-22-yl)-4-((E)-2-(1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)ethenyl)-2,6-dimethylpyridinium hydrotrifluoroacetate trifluoroacetate
CAS No.:1310327-54-8
Molecular Formula:C₂F₃O₂*C₂HF₃O₂*C₅₇H₇₀N₇O₇
Molecular Weight:1192.27
Hs Code.:

1-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11-dioxo-14,17,20-trioxa-2,8 ,10-triazadocos-9-en-22-yl)-4-((E)-2-(1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)ethenyl)-2,6-dimethylpyridinium hydrotrifluoroacetate trifluoroacetate

Synonyms:1-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11-dioxo-14,17,20-trioxa-2,8 ,10-triazadocos-9-en-22-yl)-4-((E)-2-(1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)ethenyl)-2,6-dimethylpyridinium hydrotrifluoroacetate trifluoroacetate

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Chemical Property of 1-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11-dioxo-14,17,20-trioxa-2,8 ,10-triazadocos-9-en-22-yl)-4-((E)-2-(1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)ethenyl)-2,6-dimethylpyridinium hydrotrifluoroacetate trifluoroacetate

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Technology Process of 1-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11-dioxo-14,17,20-trioxa-2,8 ,10-triazadocos-9-en-22-yl)-4-((E)-2-(1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)ethenyl)-2,6-dimethylpyridinium hydrotrifluoroacetate trifluoroacetate

There total 6 articles about 1-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11-dioxo-14,17,20-trioxa-2,8 ,10-triazadocos-9-en-22-yl)-4-((E)-2-(1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)ethenyl)-2,6-dimethylpyridinium hydrotrifluoroacetate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: (R)-Nω-(12-amino-4,7,10-trioxadodecanoyl)-Nα-(2,2-diphenylacetyl)-N-(4-hydroxybenzyl)argininamide bis(hydrotrifluoroacetate)

: 76-05-1
trifluoroacetic acid

: 2,6-dimethyl-4-[(E)-2-(2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-9-yl)vinyl]pyranylium tetrafluoroborate

: 1310327-54-8
1-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11-dioxo-14,17,20-trioxa-2,8 ,10-triazadocos-9-en-22-yl)-4-((E)-2-(1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)ethenyl)-2,6-dimethylpyridinium hydrotrifluoroacetate trifluoroacetate

Guidance literature:: (R)-Nω-(12-amino-4,7,10-trioxadodecanoyl)-Nα-(2,2-diphenylacetyl)-N-(4-hydroxybenzyl)argininamide bis(hydrotrifluoroacetate); 2,6-dimethyl-4-[(E)-2-(2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-9-yl)vinyl]pyranylium tetrafluoroborate; With triethylamine; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃;

trifluoroacetic acid; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.03.045

Reference yield:

: 252881-74-6,872340-65-3
tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate

: 1310327-54-8
1-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11-dioxo-14,17,20-trioxa-2,8 ,10-triazadocos-9-en-22-yl)-4-((E)-2-(1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)ethenyl)-2,6-dimethylpyridinium hydrotrifluoroacetate trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h

3.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 20 °C

3.2: 20 h / 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

5.1: dichloromethane / 20 °C

6.1: triethylamine / N,N-dimethyl-formamide; acetonitrile / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.03.045

Reference yield:

: 1310327-18-4,1334177-88-6
3-oxo-1-phenyl-2,7,10,13-tetraoxa-4-azahexadecan-16-oic acid

: 1310327-54-8
1-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11-dioxo-14,17,20-trioxa-2,8 ,10-triazadocos-9-en-22-yl)-4-((E)-2-(1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)ethenyl)-2,6-dimethylpyridinium hydrotrifluoroacetate trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 20 °C

1.2: 20 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

3.1: dichloromethane / 20 °C

4.1: triethylamine / N,N-dimethyl-formamide; acetonitrile / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; 1,1'-carbonyldiimidazole; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.03.045