(S)-tert-butyl 3-((R)-1-((2S,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-ylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Name:(S)-tert-butyl 3-((R)-1-((2S,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-ylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:906537-55-1
Molecular Formula:C₄₂H₅₀N₄O₅
Molecular Weight:690.883
Hs Code.:

(S)-tert-butyl 3-((R)-1-((2S,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-ylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Synonyms:(S)-tert-butyl 3-((R)-1-((2S,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-ylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of (S)-tert-butyl 3-((R)-1-((2S,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-ylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Technology Process of (S)-tert-butyl 3-((R)-1-((2S,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-ylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 8 articles about (S)-tert-butyl 3-((R)-1-((2S,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-ylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 906537-54-0
(S)-tert-butyl 3-((R)-1-((2S,4S)-2-(3-azidopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-ylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 906537-55-1
(S)-tert-butyl 3-((R)-1-((2S,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-ylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With pyridine; hydrogen; palladium on activated charcoal; In methanol; for 5h;
DOI:10.1021/jm060384p

Reference yield:

: 906537-08-4
(2S,4S)-2-(3-azidopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidine

: 906537-55-1
(S)-tert-butyl 3-((R)-1-((2S,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-ylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: HOAt; 4-methylmorpholine; ethyldimethylaminopropyl carbodiimide / dimethylformamide / 1.25 h

2: aq. TFA / CH₂Cl₂ / 1 h

3: 87 percent / 1H-benzotriazole; 4-methylmorpholine; ethyldimethylaminopropyl carbodiimide / dimethylformamide / 1 h

4: H₂; pyridine / Pd/C / methanol / 5 h

With 4-methyl-morpholine; pyridine; 1,2,3-Benzotriazole; 1-hydroxy-7-aza-benzotriazole; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm060384p

Reference yield:

: tert-butyl (4S)-2-allyl-4-(naphthalen-2-ylmethoxy)pyrrolidine-1-carboxylate

: 906537-55-1
(S)-tert-butyl 3-((R)-1-((2S,4S)-2-(3-aminopropyl)-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-ylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: BH₃-THF / tetrahydrofuran / 0.5 h

1.2: 1.1 g / aq. NaOH; H₂O₂ / tetrahydrofuran / 2 h

2.1: Et₃N / CH₂Cl₂ / 0.75 h / 20 °C

3.1: NaN₃ / dimethylsulfoxide / 3 h / 70 °C

4.1: aq. TFA / CH₂Cl₂ / 1 h

5.1: HOAt; 4-methylmorpholine; ethyldimethylaminopropyl carbodiimide / dimethylformamide / 1.25 h

6.1: aq. TFA / CH₂Cl₂ / 1 h

7.1: 87 percent / 1H-benzotriazole; 4-methylmorpholine; ethyldimethylaminopropyl carbodiimide / dimethylformamide / 1 h

8.1: H₂; pyridine / Pd/C / methanol / 5 h

With 4-methyl-morpholine; pyridine; 1,2,3-Benzotriazole; sodium azide; 1-hydroxy-7-aza-benzotriazole; borane-THF; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm060384p