Technology Process of 7,8-bis-benzyloxy-1-oxo-6-[3-(1,4,5,6,8-pentamethoxy-3-triethylsilanyloxy-naphthalen-2-ylmethyl)-4,5-dihydro-isoxazol-5-yl]-1H-isochromene-3-carboxylic acid methyl ester
There total 17 articles about 7,8-bis-benzyloxy-1-oxo-6-[3-(1,4,5,6,8-pentamethoxy-3-triethylsilanyloxy-naphthalen-2-ylmethyl)-4,5-dihydro-isoxazol-5-yl]-1H-isochromene-3-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
phenyl isocyanate; triethylamine;
In
benzene;
at 20 ℃;
for 48h;
DOI:10.1021/ol061112j
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: BBr3 / CH2Cl2 / 2 h / -78 - 20 °C
2.1: 1.31 g / K2CO3 / dimethylformamide / 20 °C
3.1: 95 percent / TMEDA / toluene / 48 h / 20 °C
4.1: TsOH / toluene / 20 h / Heating
4.2: 88 percent / K2CO3 / dimethylformamide / 5 h / 20 °C
5.1: 79 percent / phenyl isocyanate; triethylamine / benzene / 48 h / 20 °C
With
N,N,N,N,-tetramethylethylenediamine; boron tribromide; potassium carbonate; phenyl isocyanate; toluene-4-sulfonic acid; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/ol061112j
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 100 percent / imidazole / dimethylformamide / 20 °C
2: 88 percent / DDQ / CH2Cl2; H2O / 1 h / 20 °C
3: 93 percent / NH4OAc / 0.75 h / Heating
4: 100 percent / sodium borohydride; silica gel / CHCl3; propan-2-ol / 1.5 h / 20 °C
5: 95 percent / aq. HCl / methanol / 0.5 h / 20 °C
6: 96 percent / Dess-Martin periodinane / CH2Cl2 / 0.75 h / 20 °C
7: B(OH)3; H2O2; H2SO4 / tetrahydrofuran; H2O / 9 h / 20 °C
8: 196 mg / imidazole / CH2Cl2; dimethylformamide / 1 h / 20 °C
9: 79 percent / phenyl isocyanate; triethylamine / benzene / 48 h / 20 °C
With
1H-imidazole; hydrogenchloride; sodium tetrahydroborate; sulfuric acid; ammonium acetate; dihydrogen peroxide; boric acid; silica gel; Dess-Martin periodane; phenyl isocyanate; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; isopropyl alcohol; benzene;
3: Henry condensation / 7: Dakin oxidation;
DOI:10.1021/ol061112j
