(2S,3S,3aS)-2-Methyl-3-((R)-toluene-4-sulfinyl)-hexahydro-pyrrolo[1,2-b]isoxazole

Base Information

• Chemical Name: (2S,3S,3aS)-2-Methyl-3-((R)-toluene-4-sulfinyl)-hexahydro-pyrrolo[1,2-b]isoxazole
• CAS No.: 187655-42-1
• Molecular Formula: C₁₄H₁₉NO₂S
• Molecular Weight: 265.376
• Mol file: 187655-42-1.mol

Synonyms:(2S,3S,3aS)-2-Methyl-3-((R)-toluene-4-sulfinyl)-hexahydro-pyrrolo[1,2-b]isoxazole

Chemical Property of (2S,3S,3aS)-2-Methyl-3-((R)-toluene-4-sulfinyl)-hexahydro-pyrrolo[1,2-b]isoxazole

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (2S,3S,3aS)-2-Methyl-3-((R)-toluene-4-sulfinyl)-hexahydro-pyrrolo[1,2-b]isoxazole

There total 1 articles about (2S,3S,3aS)-2-Methyl-3-((R)-toluene-4-sulfinyl)-hexahydro-pyrrolo[1,2-b]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-pyrroline N-oxide (24423-88-9) + (-)-(R,Z)-1-(p-methylphenylsulfinyl)prop-1-ene (33418-16-5) → (2R,3R,3aR)-2-Methyl-3-((R)-toluene-4-sulfinyl)-hexahydro-pyrrolo[1,2-b]isoxazole + (2S,3S,3aS)-2-Methyl-3-((R)-toluene-4-sulfinyl)-hexahydro-pyrrolo[1,2-b]isoxazole (187655-42-1)

Guidance literature:

In diethyl ether; for 408h; Ambient temperature;

DOI:10.1016/S0957-4166(96)00480-6

Reference yield: 91.0%

(2S,3S,3aS)-2-Methyl-3-((R)-toluene-4-sulfinyl)-hexahydro-pyrrolo[1,2-b]isoxazole (187655-42-1) → (2S,3S,3aS)-2-Methyl-3-p-tolylsulfanyl-hexahydro-pyrrolo[1,2-b]isoxazole

Guidance literature:

With trimethylsilyl iodide; sodium iodide; In acetonitrile; Ambient temperature;

DOI:10.1016/S0957-4166(96)00480-6

Reference yield: 85.0%

(2S,3S,3aS)-2-Methyl-3-((R)-toluene-4-sulfinyl)-hexahydro-pyrrolo[1,2-b]isoxazole (187655-42-1) → (1S,2S)-1-(S)-Pyrrolidin-2-yl-1-((R)-toluene-4-sulfinyl)-propan-2-ol (187655-47-6)

Guidance literature:

With potassium hydroxide; nickel; aluminium; In methanol; for 2.25h; Ambient temperature;

DOI:10.1016/S0957-4166(96)00480-6

upstream raw materials:

1-pyrroline N-oxide

(-)-(R,Z)-1-(p-methylphenylsulfinyl)prop-1-ene

Downstream raw materials:

(1S,2S)-1-(S)-Pyrrolidin-2-yl-1-((R)-toluene-4-sulfinyl)-propan-2-ol