3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxylic acid

Base Information

Chemical Name:3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxylic acid
CAS No.:1253734-23-4
Molecular Formula:C₂₃H₂₂BrF₂N₃O₃Si
Molecular Weight:534.432
Hs Code.:

Synonyms:3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxylic acid

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Chemical Property of 3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxylic acid

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Technology Process of 3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxylic acid

There total 8 articles about 3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253734-21-2
3-bromo-5-(2,6-difluorophenyl)-2H-pyrazolo[4,3-c]isoquinoline-7-carboxylic acid

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1253734-22-3
3-bromo-5-(2,6-difluorophenyl)-2-{[2-(trimethylsilyl)ethoxy]methyl}-2H-pyrazolo[4,3-c]isoquinoline-7-carboxylic acid

: 1253734-23-4
3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxylic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1253733-69-5
2,6-difluoro-N-[5-(4-iodophenyl)-1H-pyrazol-4-yl]benzamide

: 1253734-23-4
3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / Inert atmosphere

2.2: 16 h / 20 °C

3.1: palladium-triphenylphosphine / N,N-dimethyl-formamide / 3.17 h / Inert atmosphere; Reflux

4.1: osmium(VIII) oxide; sodium periodate / water; tert-butyl alcohol; tetrahydrofuran

5.1: potassium permanganate / water; acetone / 1 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

7.1: potassium hydroxide; bromine / N,N-dimethyl-formamide / 1 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With potassium permanganate; sodium periodate; osmium(VIII) oxide; phosphorus pentoxide; bromine; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; palladium-triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; mineral oil; tert-butyl alcohol;

Reference yield:

: 1253733-71-9
5-(2,6-difluorophenyl)-7-iodo-1H-pyrazolo[4,3-c]isoquinoline

: 1253734-23-4
3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / Inert atmosphere

1.2: 16 h / 20 °C

2.1: palladium-triphenylphosphine / N,N-dimethyl-formamide / 3.17 h / Inert atmosphere; Reflux

3.1: osmium(VIII) oxide; sodium periodate / water; tert-butyl alcohol; tetrahydrofuran

4.1: potassium permanganate / water; acetone / 1 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

6.1: potassium hydroxide; bromine / N,N-dimethyl-formamide / 1 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With potassium permanganate; sodium periodate; osmium(VIII) oxide; bromine; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; palladium-triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; mineral oil; tert-butyl alcohol;