C₃₁H₄₆N₄OSi

Base Information

• Chemical Name: C₃₁H₄₆N₄OSi
• CAS No.: 949536-09-8
• Molecular Formula: C₃₁H₄₆N₄OSi
• Molecular Weight: 518.818
• Mol file: 949536-09-8.mol

Synonyms:C₃₁H₄₆N₄OSi

Chemical Property of C₃₁H₄₆N₄OSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₁H₄₆N₄OSi

There total 8 articles about C₃₁H₄₆N₄OSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H39ClN2OSi (476645-28-0) + 4-amino-3-methylbenzonitrile (78881-21-7) → C31H46N4OSi (949536-09-8)

Guidance literature:

With potassium phosphate; 2-(dicyclohexylphosphino)-2'-methylbiphenyl; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In 1,2-dimethoxyethane; at 100 ℃; for 0.333333h; under 3102.97 Torr; microwave irradiation;

DOI:10.1016/j.bmcl.2007.06.077

Reference yield:

C18H25ClN2O (476645-25-7) → C31H46N4OSi (949536-09-8)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. HCl / 1.5 h / 70 °C

2: NaBH₄ / methanol / 1 h / 0 °C

3: imidazole; DMAP / dimethylformamide / 20 °C

4: 2-(dicyclohexylphosphino)-2'-methylbiphenyl; K₃PO₄ / Pd₂(dba)3 / 1,2-dimethoxy-ethane / 0.33 h / 100 °C / 3102.97 Torr / microwave irradiation

With 1H-imidazole; hydrogenchloride; dmap; sodium tetrahydroborate; potassium phosphate; 2-(dicyclohexylphosphino)-2'-methylbiphenyl; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; 4: Buchwald amination;

DOI:10.1016/j.bmcl.2007.06.077

Reference yield:

C16H21ClN2O (476645-31-5) → C31H46N4OSi (949536-09-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: BuLi / tetrahydrofuran / 0.17 h / 0 °C

1.2: tetrahydrofuran / 20 °C

2.1: aq. HCl / 1.5 h / 70 °C

3.1: NaBH₄ / methanol / 1 h / 0 °C

4.1: imidazole; DMAP / dimethylformamide / 20 °C

5.1: 2-(dicyclohexylphosphino)-2'-methylbiphenyl; K₃PO₄ / Pd₂(dba)3 / 1,2-dimethoxy-ethane / 0.33 h / 100 °C / 3102.97 Torr / microwave irradiation

With 1H-imidazole; hydrogenchloride; dmap; sodium tetrahydroborate; potassium phosphate; n-butyllithium; 2-(dicyclohexylphosphino)-2'-methylbiphenyl; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; 5.1: Buchwald amination;

DOI:10.1016/j.bmcl.2007.06.077

upstream raw materials:

C₂₃H₃₉ClN₂OSi

4-amino-3-methylbenzonitrile

C₁₅H₂₁ClN₂

C₁₆H₂₁ClN₂O

Downstream raw materials:

C₂₅H₃₂N₄O