3-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)propanoic acid

Base Information

Chemical Name:3-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)propanoic acid
CAS No.:913622-85-2
Molecular Formula:C₂₃H₂₆ClNO₁₃
Molecular Weight:559.911
Hs Code.:

Synonyms:3-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)propanoic acid

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Chemical Property of 3-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)propanoic acid

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Technology Process of 3-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)propanoic acid

There total 8 articles about 3-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-chloro-4,6-dihydroxy-2-(3-oxo-propyl)-benzoic acid 2-(2-methoxy-3,6-bis-methoxymethoxy-5-nitro-phenyl)-ethyl ester

: 913622-85-2
3-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)propanoic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 0.5h;
DOI:10.1021/jo061054f

Reference yield:

: 811788-12-2
methyl 2-(but-3-enyl)-4,6-bis(tert-butyldimethylsilanyloxy)-3-chlorobenzoate

: 913622-85-2
3-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: LiOH

1.2: 83 percent / nPrSLi

2.1: 90 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 10 h / 0 - 20 °C

3.1: OsO₄; NaIO₄; 2,6-lutidine / dioxane; H₂O / 2 h / 20 °C

4.1: 302 mg / 2-methyl-2-butene; NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 0.5 h / 20 °C

With 2,6-dimethylpyridine; lithium hydroxide; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; water; tert-butyl alcohol; 2.1: Mitsunobu esterification;
DOI:10.1021/jo061054f

Reference yield:

: 884861-57-8
2-but-3-enyl-3-chloro-4,6-dihydroxy-benzoic acid

: 913622-85-2
3-(2-chloro-3,5-dihydroxy-6-((2-methoxy-3,6-bis(methoxymethoxy)-5-nitrophenethyloxy)carbonyl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 10 h / 0 - 20 °C

2: OsO₄; NaIO₄; 2,6-lutidine / dioxane; H₂O / 2 h / 20 °C

3: 302 mg / 2-methyl-2-butene; NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 0.5 h / 20 °C

With 2,6-dimethylpyridine; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; water; tert-butyl alcohol; 1: Mitsunobu esterification;
DOI:10.1021/jo061054f