(2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid N-(3-cyanophenyl)amide

Base Information

Chemical Name:(2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid N-(3-cyanophenyl)amide
CAS No.:1087058-46-5
Molecular Formula:C₁₉H₁₄N₂O₃
Molecular Weight:318.332
Hs Code.:

Synonyms:(2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid N-(3-cyanophenyl)amide

Suppliers and Price of (2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid N-(3-cyanophenyl)amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid N-(3-cyanophenyl)amide

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Technology Process of (2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid N-(3-cyanophenyl)amide

There total 4 articles about (2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid N-(3-cyanophenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 2237-30-1
m-cyanoaniline

: 136-72-1
piperic acid

: 1087058-46-5
(2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid N-(3-cyanophenyl)amide

Guidance literature:: piperic acid; With thionyl chloride; In dichloromethane; for 1h; Reflux;

m-cyanoaniline; In dichloromethane; for 1h;
DOI:10.1016/j.bmc.2008.09.042

Reference yield:

: 2237-30-1
m-cyanoaniline

: 700359-91-7
piperic acid mesylate

: 1087058-46-5
(2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid N-(3-cyanophenyl)amide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.freeradbiomed.2021.04.026

Reference yield:

: 94-62-2,7780-20-3
Piperine

: 1087058-46-5
(2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid N-(3-cyanophenyl)amide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / methanol / 48 h / 20 °C

2: triethylamine / dichloromethane / 45 h / 0 °C

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With triethylamine; potassium hydroxide; In methanol; dichloromethane;
DOI:10.1016/j.freeradbiomed.2021.04.026