pyridine-2,6-dicarboxylic acid bis-{[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-propyl]-amide}

Base Information

• Chemical Name: pyridine-2,6-dicarboxylic acid bis-{[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-propyl]-amide}
• CAS No.: 934564-58-6
• Molecular Formula: C₄₇H₅₉N₃O₆Si₂
• Molecular Weight: 818.173

Synonyms:pyridine-2,6-dicarboxylic acid bis-{[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-propyl]-amide}

Chemical Property of pyridine-2,6-dicarboxylic acid bis-{[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-propyl]-amide}

Chemical Property:

Purity/Quality:

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Technology Process of pyridine-2,6-dicarboxylic acid bis-{[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-propyl]-amide}

There total 3 articles about pyridine-2,6-dicarboxylic acid bis-{[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-propyl]-amide} which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

3-(tert-butyl-diphenyl-silanyloxy)-2-({6-[2-(tert-butyl-diphenyl-silanyloxy)-1-methoxycarbonyl-propylcarbamoyl]-pyridine-2-carbonyl}-amino)-butyric acid methyl ester (934564-57-5) → pyridine-2,6-dicarboxylic acid bis-{[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-propyl]-amide} (934564-58-6)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

DOI:10.1021/jo0621470

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → pyridine-2,6-dicarboxylic acid bis-{[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-propyl]-amide} (934564-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / imidazole / CH₂Cl₂ / 12 h / 20 °C

2: 42 percent / LiBH₄ / tetrahydrofuran / 12 h / 0 - 20 °C

With 1H-imidazole; lithium borohydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo0621470

Reference yield:

2,6-bis[(1'-(S)-carbomethoxy-2'-(R)-hydroxy)propylcarbamoyl]pyridine (578709-64-5) → pyridine-2,6-dicarboxylic acid bis-{[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-propyl]-amide} (934564-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / imidazole / CH₂Cl₂ / 12 h / 20 °C

2: 42 percent / LiBH₄ / tetrahydrofuran / 12 h / 0 - 20 °C

With 1H-imidazole; lithium borohydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo0621470

upstream raw materials:

3-(tert-butyl-diphenyl-silanyloxy)-2-({6-[2-(tert-butyl-diphenyl-silanyloxy)-1-methoxycarbonyl-propylcarbamoyl]-pyridine-2-carbonyl}-amino)-butyric acid methyl ester

tert-butylchlorodiphenylsilane

2,6-bis[(1'-(S)-carbomethoxy-2'-(R)-hydroxy)propylcarbamoyl]pyridine

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