ethyl 2-chloro-4-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]butyrate

Base Information

Chemical Name:ethyl 2-chloro-4-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]butyrate
CAS No.:178238-88-5
Molecular Formula:C₂₄H₂₆ClNO₄
Molecular Weight:427.928
Hs Code.:

Synonyms:ethyl 2-chloro-4-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]butyrate

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Chemical Property of ethyl 2-chloro-4-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]butyrate

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Technology Process of ethyl 2-chloro-4-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]butyrate

There total 5 articles about ethyl 2-chloro-4-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 159017-43-3
ethyl 2-hydroxy-4-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]butyrate

: 178238-88-5
ethyl 2-chloro-4-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]butyrate

Guidance literature:: With thionyl chloride; for 2h; Heating;
DOI:10.1021/jm010490l

Reference yield:

: 103788-59-6
4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzaldehyde

: 178238-88-5
ethyl 2-chloro-4-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]butyrate

Guidance literature:: Multi-step reaction with 5 steps

1: aq. Na₂CO₃ / methanol / 24 h / Heating

2: HCl / 0.5 h / Heating

3: H₂ / 10percent Pd/C / dioxane / atmospheric pressure

4: 550 mg / NaBH₄ / ethanol / 1 h / 20 °C

5: 63 percent / SOCl₂ / 2 h / Heating

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; hydrogen; sodium carbonate; 10percent Pd/C; In 1,4-dioxane; methanol; ethanol;
DOI:10.1021/jm010490l

Reference yield:

: (E)-4-{4-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2-oxo-but-3-enoic acid

: 178238-88-5
ethyl 2-chloro-4-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]butyrate

Guidance literature:: Multi-step reaction with 4 steps

1: HCl / 0.5 h / Heating

2: H₂ / 10percent Pd/C / dioxane / atmospheric pressure

3: 550 mg / NaBH₄ / ethanol / 1 h / 20 °C

4: 63 percent / SOCl₂ / 2 h / Heating

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; hydrogen; 10percent Pd/C; In 1,4-dioxane; ethanol;
DOI:10.1021/jm010490l