Boc-Asp-Tyr(SO₃K)-Nle-Gly-Trp-Nle-gAsp-COCH₂CH₂C₆H₅

Base Information

• Chemical Name: Boc-Asp-Tyr(SO₃K)-Nle-Gly-Trp-Nle-gAsp-COCH₂CH₂C₆H₅
• CAS No.: 121961-23-7
• Molecular Formula: C₅₅H₇₂N₉O₁₇S*K
• Molecular Weight: 1202.39
• Mol file: 121961-23-7.mol

Synonyms:Boc-Asp-Tyr(SO₃K)-Nle-Gly-Trp-Nle-gAsp-COCH₂CH₂C₆H₅

Chemical Property of Boc-Asp-Tyr(SO₃K)-Nle-Gly-Trp-Nle-gAsp-COCH₂CH₂C₆H₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Asp-Tyr(SO₃K)-Nle-Gly-Trp-Nle-gAsp-COCH₂CH₂C₆H₅

There total 8 articles about Boc-Asp-Tyr(SO₃K)-Nle-Gly-Trp-Nle-gAsp-COCH₂CH₂C₆H₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

Boc-Asp-Tyr-Nle-Gly-Trp-Nle-gAsp-COCH2CH2C6H5 (121888-38-8) → Boc-Asp-Tyr(SO3K)-Nle-Gly-Trp-Nle-gAsp-COCH2CH2C6H5 (121961-23-7)

Guidance literature:

With pyridine-SO₃ complex; In pyridine; N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm00130a018

Reference yield:

Boc-Nle-OH (6404-28-0) → Boc-Asp-Tyr(SO3K)-Nle-Gly-Trp-Nle-gAsp-COCH2CH2C6H5 (121961-23-7)

Guidance literature:

Multi-step reaction with 8 steps

1: 1) N-methylmorpholine, isobutyl chloroformate, 2) N,N-diisopropylethylamine / 1) DMF, 0 deg C, 5 min, 2) a) 0 deg C, 30 min, b) r.t., 30 min

2: benzene / acetonitrile / 3 h / Ambient temperature

3: (benzotriazolyloxy)tris(dimethylamino)phosphonium hexafluorophosphate, N,N-diisopropylethylamine / dimethylformamide / 1 h / Ambient temperature

4: 1) F₃COOH, 2) N,N-diisopropylethylamine / 1) r.t., 30 min, 2) DMF, r.t., 3 h

5: H₂ / 10percent Pd/C / dimethylformamide; acetic acid; H₂O / 7 h / 760 Torr / Ambient temperature

6: N,N-diisopropylethylamine / dimethylformamide / 3 h / Ambient temperature

7: 98 percent / H₂ / 10percent Pd/C / dimethylformamide; acetic acid; H₂O / 4 h / 760 Torr / Ambient temperature

8: 65 percent / SO₃-pyridine complex / dimethylformamide; pyridine / Ambient temperature

With 4-methyl-morpholine; bis-(trifluoroacetoxy)-iodo-benzene; pyridine-SO₃ complex; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In pyridine; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm00130a018

Reference yield:

Boc-L-Nle-L-Asp(Bzl)-NH2 (94236-49-4) → Boc-Asp-Tyr(SO3K)-Nle-Gly-Trp-Nle-gAsp-COCH2CH2C6H5 (121961-23-7)

Guidance literature:

Multi-step reaction with 7 steps

1: benzene / acetonitrile / 3 h / Ambient temperature

2: (benzotriazolyloxy)tris(dimethylamino)phosphonium hexafluorophosphate, N,N-diisopropylethylamine / dimethylformamide / 1 h / Ambient temperature

3: 1) F₃COOH, 2) N,N-diisopropylethylamine / 1) r.t., 30 min, 2) DMF, r.t., 3 h

4: H₂ / 10percent Pd/C / dimethylformamide; acetic acid; H₂O / 7 h / 760 Torr / Ambient temperature

5: N,N-diisopropylethylamine / dimethylformamide / 3 h / Ambient temperature

6: 98 percent / H₂ / 10percent Pd/C / dimethylformamide; acetic acid; H₂O / 4 h / 760 Torr / Ambient temperature

7: 65 percent / SO₃-pyridine complex / dimethylformamide; pyridine / Ambient temperature

With bis-(trifluoroacetoxy)-iodo-benzene; pyridine-SO₃ complex; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In pyridine; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm00130a018

upstream raw materials:

Boc-Asp-Tyr-Nle-Gly-Trp-Nle-gAsp-COCH₂CH₂C₆H₅

Boc-Nle-OH

Boc-L-Nle-L-Asp(Bzl)-NH₂

Boc-Nle-gAsp(OBzl)-COCH₂CH₂C₆H₅

Refernces