(S)-2-[N-(6'-hydroxyhexyl)carbamoyl]oxy-1-(4-monomethoxytrityl)aminopropane

Base Information

• Chemical Name: (S)-2-[N-(6'-hydroxyhexyl)carbamoyl]oxy-1-(4-monomethoxytrityl)aminopropane
• CAS No.: 922522-09-6
• Molecular Formula: C₃₀H₃₈N₂O₄
• Molecular Weight: 490.643

Synonyms:(S)-2-[N-(6'-hydroxyhexyl)carbamoyl]oxy-1-(4-monomethoxytrityl)aminopropane

Chemical Property of (S)-2-[N-(6'-hydroxyhexyl)carbamoyl]oxy-1-(4-monomethoxytrityl)aminopropane

Chemical Property:

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Technology Process of (S)-2-[N-(6'-hydroxyhexyl)carbamoyl]oxy-1-(4-monomethoxytrityl)aminopropane

There total 1 articles about (S)-2-[N-(6'-hydroxyhexyl)carbamoyl]oxy-1-(4-monomethoxytrityl)aminopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(S)-1-(4-monomethoxytrityl)amino-2-propanol (922522-08-5) + 6-amino-1-hexanol (4048-33-3) + 1,1'-carbonyldiimidazole (530-62-1) → (S)-2-[N-(6'-hydroxyhexyl)carbamoyl]oxy-1-(4-monomethoxytrityl)aminopropane (922522-09-6)

Guidance literature:

(S)-1-(4-monomethoxytrityl)amino-2-propanol; 1,1'-carbonyldiimidazole; With dmap; In N,N-dimethyl-formamide; at 20 ℃; for 7h;

6-amino-1-hexanol; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Further stages.;

DOI:10.1016/j.bmc.2007.10.011

Reference yield: 62.0%

(S)-2-[N-(6'-hydroxyhexyl)carbamoyl]oxy-1-(4-monomethoxytrityl)aminopropane (922522-09-6) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → (S)-2-[N-(6'-hydroxyhexyl)carbamoyl]oxy-1-(4-monomethoxytrityl)aminopropane 6'-O-(2-cyanoethyl-N,N-diisopropylphosphoramidite) (922522-10-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmc.2007.10.011

upstream raw materials:

(S)-1-(4-monomethoxytrityl)amino-2-propanol

6-amino-1-hexanol

1,1'-carbonyldiimidazole

Downstream raw materials:

(S)-2-[N-(6'-hydroxyhexyl)carbamoyl]oxy-1-(4-monomethoxytrityl)aminopropane 6'-O-(2-cyanoethyl-N,N-diisopropylphosphoramidite)

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