α-phenyl-4-quinolinemethanol

Base Information

• Chemical Name: α-phenyl-4-quinolinemethanol
• CAS No.: 108771-06-8
• Molecular Formula: C₁₆H₁₃NO
• Molecular Weight: 235.285
• Mol file: 108771-06-8.mol

Synonyms:α-phenyl-4-quinolinemethanol

Chemical Property of α-phenyl-4-quinolinemethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-phenyl-4-quinolinemethanol

There total 7 articles about α-phenyl-4-quinolinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

quinoline-4-carboxaldehyde (4363-93-3) + phenylboronic acid (98-80-6) → α-phenyl-4-quinolinemethanol (108771-06-8)

Guidance literature:

With cesium fluoride; bis(η3-allyl-μ-chloropalladium(II)); In 1,4-dioxane; at 80 ℃; for 3h;

DOI:10.1021/jo7020983

Reference yield: 93.0%

quinoline-4-carboxaldehyde (4363-93-3) + potassium phenyltrifluoborate → α-phenyl-4-quinolinemethanol (108771-06-8)

Guidance literature:

With caesium carbonate; bis(η3-allyl-μ-chloropalladium(II)); In water; toluene; at 100 ℃; for 2h;

DOI:10.1021/jo801352h

Reference yield: 60.0%

4-benzylquinoline (5632-14-4) → α-phenyl-4-quinolinemethanol (108771-06-8)

Guidance literature:

With potassium tert-butylate; dimethyl sulfoxide; at 30 ℃; for 0.1h; chemoselective reaction;

DOI:10.1021/acs.orglett.0c03108

upstream raw materials:

benzaldehyde

4-(Toluene-4-sulfinyl)-quinoline

4-bromoquinoline

quinoline-4-carboxaldehyde

Refernces

• 1、 -. "Green synthesis method of polyaryl substituted methanol". Paragraph 0127-0131; 0232-0236. . Retrieved 2021/04/17.
• 2、 Bieszczad, Bartosz,Perego, Luca Alessandro,Melchiorre, Paolo. "Photochemical C?H Hydroxyalkylation of Quinolines and Isoquinolines". supporting information. p. 16878 - 16883. Retrieved 2019/11/13.