C₂₃H₂₆N₄O₅

Base Information

• Chemical Name: C₂₃H₂₆N₄O₅
• CAS No.: 1428306-00-6
• Molecular Formula: C₂₃H₂₆N₄O₅
• Molecular Weight: 438.483
• Mol file: 1428306-00-6.mol

Synonyms:C₂₃H₂₆N₄O₅

Chemical Property of C₂₃H₂₆N₄O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₆N₄O₅

There total 7 articles about C₂₃H₂₆N₄O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H28N4O5 (1428305-96-7) → C23H26N4O5 (1428306-00-6)

Guidance literature:

With lithium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 3h;

DOI:10.1021/jm301882a

Reference yield:

1-methyl-2-trichloroacetyl-1H-pyrrole (21898-65-7) → C23H26N4O5 (1428306-00-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 6 h / -10 - 20 °C

2.1: sodium methylate / 0.5 h / Reflux

2.2: pH 2

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene; water / 100 °C / Microwave irradiation; Inert atmosphere

4.1: sodium hydroxide / 1,4-dioxane / 6 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 6 h / 20 °C

6.1: lithium hydroxide / water; 1,4-dioxane / 3 h / 20 °C

With dmap; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; 3.1: |Suzuki Coupling;

DOI:10.1021/jm301882a

Reference yield:

4-bromo-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester (1196-90-3) → C23H26N4O5 (1428306-00-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene; water / 100 °C / Microwave irradiation; Inert atmosphere

2.1: sodium hydroxide / 1,4-dioxane / 6 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 6 h / 20 °C

4.1: lithium hydroxide / water; 1,4-dioxane / 3 h / 20 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; lithium hydroxide; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; 1.1: |Suzuki Coupling;

DOI:10.1021/jm301882a

upstream raw materials:

1-methyl-2-trichloroacetyl-1H-pyrrole

1-(4-bromo-1-methyl-1H-pyrrol-2-yl)-2,2,2-trichloroethan-1-one

N-Methylpyrrole

4-bromo-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester

Downstream raw materials:

C₃₀H₃₄N₆O₆

methyl 4-(4-(4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate

(S)-methyl 4-(4-(4-(4-(4-((7-methoxy-5-oxo-2,3,5,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yl)oxy)butanamido)phenyl)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate