(3R)-3-(2-(2-amino-2-phenylacetamido)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane 2.2,2-trifluoroacetate

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Chemical Name:(3R)-3-(2-(2-amino-2-phenylacetamido)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane 2.2,2-trifluoroacetate
CAS No.:1379514-68-7
Molecular Formula:C₂F₃O₂*C₃₁H₃₄N₃O₄
Molecular Weight:625.645
Hs Code.:

Synonyms:(3R)-3-(2-(2-amino-2-phenylacetamido)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane 2.2,2-trifluoroacetate

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Chemical Property of (3R)-3-(2-(2-amino-2-phenylacetamido)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane 2.2,2-trifluoroacetate

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Technology Process of (3R)-3-(2-(2-amino-2-phenylacetamido)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane 2.2,2-trifluoroacetate

There total 6 articles about (3R)-3-(2-(2-amino-2-phenylacetamido)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane 2.2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.9%

: 1379514-66-5
(3R)-3-(2-(2-(tert-butoxycarbonylamino)-2-phenylacetamido)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride

: 76-05-1
trifluoroacetic acid

: 1379514-68-7
(3R)-3-(2-(2-amino-2-phenylacetamido)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane 2.2,2-trifluoroacetate

Guidance literature:: (3R)-3-(2-(2-(tert-butoxycarbonylamino)-2-phenylacetamido)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride; With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

trifluoroacetic acid;

Reference yield:

: 2900-27-8,3601-66-9,14675-97-9,33125-05-2
2-(tert-butoxycarbonylamino)-2-phenylacetic acid

: 1379514-68-7
(3R)-3-(2-(2-amino-2-phenylacetamido)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane 2.2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.17 h / 20 °C

1.2: 15 h / 20 °C

2.1: ethyl acetate; acetonitrile / 39 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 2835-06-5
phenylglycin

: 1379514-68-7
(3R)-3-(2-(2-amino-2-phenylacetamido)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane 2.2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / acetone / 1 h / 20 °C

2.1: triethylamine / dichloromethane / 0.17 h / 20 °C

2.2: 15 h / 20 °C

3.1: ethyl acetate; acetonitrile / 39 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; triethylamine; sodium hydroxide; In 1,4-dioxane; dichloromethane; ethyl acetate; acetone; acetonitrile;