methyl (11R,14S)-4-methoxy-9,12-dioxo-11phenyl-2-oxa-10,13-diazatricyclo[14.2.2.1(3,7)]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylate

Base Information

• Chemical Name: methyl (11R,14S)-4-methoxy-9,12-dioxo-11phenyl-2-oxa-10,13-diazatricyclo[14.2.2.1(3,7)]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylate
• CAS No.: 1200443-29-3
• Molecular Formula: C₂₇H₂₆N₂O₆
• Molecular Weight: 474.513

Synonyms:methyl (11R,14S)-4-methoxy-9,12-dioxo-11phenyl-2-oxa-10,13-diazatricyclo[14.2.2.1(3,7)]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylate

Chemical Property of methyl (11R,14S)-4-methoxy-9,12-dioxo-11phenyl-2-oxa-10,13-diazatricyclo[14.2.2.1(3,7)]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylate

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Technology Process of methyl (11R,14S)-4-methoxy-9,12-dioxo-11phenyl-2-oxa-10,13-diazatricyclo[14.2.2.1(3,7)]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylate

There total 1 articles about methyl (11R,14S)-4-methoxy-9,12-dioxo-11phenyl-2-oxa-10,13-diazatricyclo[14.2.2.1(3,7)]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

5-(2-{(R)-2-[(S)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-ylamino]-2-oxo-1-phenylethylamino}-2-oxoethyl)-2-methoxyphenylboronic acid (1200443-28-2) → methyl (11R,14S)-4-methoxy-9,12-dioxo-11phenyl-2-oxa-10,13-diazatricyclo[14.2.2.1(3,7)]henicosa-1(19),3(21),4,6,16(20),17-hexaene-14-carboxylate (1200443-29-3)

Guidance literature:

With dmap; copper diacetate; In dichloromethane; at 25 ℃; for 48h; Molecular sieve; Inert atmosphere;

DOI:10.1055/s-0029-1216937

Reference yield: 80.0%

methyl (11R,14S)-4-methoxy-9,12-dioxo-11phenyl-2-oxa-10,13-diazatricyclo[14.2.2.1(3,7)]henicosa-1(19),3(21),4,6,16(20),17-hexaene-14-carboxylate (1200443-29-3) → methyl (11R,14S)-4-hydroxy-9,12-dioxo-11-phenyl-2-oxa-10,13-diazatricyclo[14.2.2.1(3,7)]henicosa-1(19),3(21),4,6,16(20),17-hexaene-14-carboxylate

Guidance literature:

With boron trichloride; tetra-(n-butyl)ammonium iodide; In dichloromethane; at -78 - 0 ℃; for 2h; Inert atmosphere;

DOI:10.1055/s-0029-1216937

upstream raw materials:

5-(2-{(R)-2-[(S)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-ylamino]-2-oxo-1-phenylethylamino}-2-oxoethyl)-2-methoxyphenylboronic acid

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