1,2-epoxy-2-methyl-1-phenylsulfinyl-3-(tetrahydropyranyloxy)propane

Base Information

• Chemical Name: 1,2-epoxy-2-methyl-1-phenylsulfinyl-3-(tetrahydropyranyloxy)propane
• CAS No.: 102104-42-7
• Molecular Formula: C₁₅H₂₀O₄S
• Molecular Weight: 296.387
• Mol file: 102104-42-7.mol

Synonyms:1,2-epoxy-2-methyl-1-phenylsulfinyl-3-(tetrahydropyranyloxy)propane

Chemical Property of 1,2-epoxy-2-methyl-1-phenylsulfinyl-3-(tetrahydropyranyloxy)propane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-epoxy-2-methyl-1-phenylsulfinyl-3-(tetrahydropyranyloxy)propane

There total 3 articles about 1,2-epoxy-2-methyl-1-phenylsulfinyl-3-(tetrahydropyranyloxy)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-Benzenesulfinyl-1-chloro-2-methyl-3-(tetrahydro-pyran-2-yloxy)-propan-2-ol (102104-40-5) → 1,2-epoxy-2-methyl-1-phenylsulfinyl-3-(tetrahydropyranyloxy)propane (102104-42-7)

Guidance literature:

With potassium hydroxide; In methanol; for 1h; Ambient temperature;

DOI:10.1246/bcsj.58.1983

Reference yield:

1-hydroxypropan-2-one tetrahydropyran ether (53343-13-8) → 1,2-epoxy-2-methyl-1-phenylsulfinyl-3-(tetrahydropyranyloxy)propane (102104-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) lithium diisopropylamide / 1) THF, -70 deg C, 20 min, 2) THF, -70 deg C, 10 min

2: 94 percent / 30percent aq. KOH / methanol / 1 h / Ambient temperature

With potassium hydroxide; lithium diisopropyl amide; In methanol;

DOI:10.1246/bcsj.58.1983

Reference yield:

chloromethyl phenyl sulfoxide (7205-94-9) → 1,2-epoxy-2-methyl-1-phenylsulfinyl-3-(tetrahydropyranyloxy)propane (102104-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) lithium diisopropylamide / 1) THF, -70 deg C, 20 min, 2) THF, -70 deg C, 10 min

2: 94 percent / 30percent aq. KOH / methanol / 1 h / Ambient temperature

With potassium hydroxide; lithium diisopropyl amide; In methanol;

DOI:10.1246/bcsj.58.1983

upstream raw materials:

1-Benzenesulfinyl-1-chloro-2-methyl-3-(tetrahydro-pyran-2-yloxy)-propan-2-ol

1-hydroxypropan-2-one tetrahydropyran ether

chloromethyl phenyl sulfoxide

Downstream raw materials:

2-methyl-3-(phenylsulfanyl)propanal

2-methyl-2-phenylthio-3-tetrahydropyranyloxypropanal