1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(4-fluoro-phenyl)-but-3-yn-1-ol

Base Information

Chemical Name:1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(4-fluoro-phenyl)-but-3-yn-1-ol
CAS No.:1026173-27-2
Molecular Formula:C₂₀H₂₀FN₃O₃S
Molecular Weight:401.462
Hs Code.:

Synonyms:1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(4-fluoro-phenyl)-but-3-yn-1-ol

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Chemical Property of 1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(4-fluoro-phenyl)-but-3-yn-1-ol

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Technology Process of 1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(4-fluoro-phenyl)-but-3-yn-1-ol

There total 6 articles about 1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(4-fluoro-phenyl)-but-3-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 528-45-0
3,4-dinitrobenzoic acid

: 1026173-27-2
1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(4-fluoro-phenyl)-but-3-yn-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: PCl₅ / 1.) RT, 10 min, 2.) RT to 45 deg C, 45 min

2: AlCl₃ / 2 h / 50 °C

3: 92 percent / H₂ / Raney nickel / tetrahydrofuran / 7 h / 3102.9 Torr / Ambient temperature

4: 65 percent / pyridine / CH₂Cl₂ / 5 h / Ambient temperature

5: 55 percent / 2N aq. NaOH / propan-2-ol; acetonitrile / Ambient temperature

6: magnesium, mercuric chloride / tetrahydrofuran; toluene / 1.5 h

With pyridine; sodium hydroxide; aluminium trichloride; phosphorus pentachloride; hydrogen; magnesium; mercury dichloride; nickel; In tetrahydrofuran; dichloromethane; isopropyl alcohol; toluene; acetonitrile;
DOI:10.1021/jm960718i

Reference yield:

: 24376-18-9
3,4-dinitrobenzoyl chloride

: 1026173-27-2
1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(4-fluoro-phenyl)-but-3-yn-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: AlCl₃ / 2 h / 50 °C

2: 92 percent / H₂ / Raney nickel / tetrahydrofuran / 7 h / 3102.9 Torr / Ambient temperature

3: 65 percent / pyridine / CH₂Cl₂ / 5 h / Ambient temperature

4: 55 percent / 2N aq. NaOH / propan-2-ol; acetonitrile / Ambient temperature

5: magnesium, mercuric chloride / tetrahydrofuran; toluene / 1.5 h

With pyridine; sodium hydroxide; aluminium trichloride; hydrogen; magnesium; mercury dichloride; nickel; In tetrahydrofuran; dichloromethane; isopropyl alcohol; toluene; acetonitrile;
DOI:10.1021/jm960718i

Reference yield:

: 97183-75-0
3,4-dinitro-4'-fluorobenzophenone

: 1026173-27-2
1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(4-fluoro-phenyl)-but-3-yn-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / H₂ / Raney nickel / tetrahydrofuran / 7 h / 3102.9 Torr / Ambient temperature

2: 65 percent / pyridine / CH₂Cl₂ / 5 h / Ambient temperature

3: 55 percent / 2N aq. NaOH / propan-2-ol; acetonitrile / Ambient temperature

4: magnesium, mercuric chloride / tetrahydrofuran; toluene / 1.5 h

With pyridine; sodium hydroxide; hydrogen; magnesium; mercury dichloride; nickel; In tetrahydrofuran; dichloromethane; isopropyl alcohol; toluene; acetonitrile;
DOI:10.1021/jm960718i