6-ethoxy-2-(3-(pyridin-2-yl)-4-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin

Base Information

Chemical Name:6-ethoxy-2-(3-(pyridin-2-yl)-4-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin
CAS No.:1383618-46-9
Molecular Formula:C₂₀H₁₅F₃N₄O
Molecular Weight:384.361
Hs Code.:

Synonyms:6-ethoxy-2-(3-(pyridin-2-yl)-4-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin

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Chemical Property of 6-ethoxy-2-(3-(pyridin-2-yl)-4-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin

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Technology Process of 6-ethoxy-2-(3-(pyridin-2-yl)-4-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin

There total 5 articles about 6-ethoxy-2-(3-(pyridin-2-yl)-4-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1383618-42-5
2-(3-bromo-4-(trifluoromethyl)phenyl)-6-ethoxyimidazo[1,2-b]pyridazine

: 81745-83-7
pyridin-2-ylzinc(ll) bromide

: 1383618-46-9
6-ethoxy-2-(3-(pyridin-2-yl)-4-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin

Guidance literature:: 2-(3-bromo-4-(trifluoromethyl)phenyl)-6-ethoxyimidazo[1,2-b]pyridazine; pyridin-2-ylzinc(ll) bromide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; at 60 ℃; for 12h;

With sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield:

: 581813-17-4
3-bromo-4-(trifluoromethyl)benzoic acid

: 1383618-46-9
6-ethoxy-2-(3-(pyridin-2-yl)-4-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 16 h / Reflux

1.2: 4 h / 20 °C

1.3: 0 °C

2.1: acetonitrile / 16 h / 80 °C

3.1: ethanol; tetrahydrofuran / 4 h / 50 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 12 h / 60 °C

With thionyl chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; ethanol; acetonitrile;

Reference yield:

: 125483-00-3
3-amino-4-(trifluoromethyl)benzoic acid

: 1383618-46-9
6-ethoxy-2-(3-(pyridin-2-yl)-4-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium nitrite; hydrogen bromide / water / 0.75 h

1.2: 18 h / 20 - 75 °C

2.1: thionyl chloride / 16 h / Reflux

2.2: 4 h / 20 °C

2.3: 0 °C

3.1: acetonitrile / 16 h / 80 °C

4.1: ethanol; tetrahydrofuran / 4 h / 50 °C

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 12 h / 60 °C

With thionyl chloride; hydrogen bromide; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; ethanol; water; acetonitrile;