5-chloro-8-(furan-2-yl)-2-(3-phenylpropyl)-2H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine

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Chemical Name:5-chloro-8-(furan-2-yl)-2-(3-phenylpropyl)-2H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine
CAS No.:1357087-50-3
Molecular Formula:C₁₉H₁₅ClN₆O
Molecular Weight:378.821
Hs Code.:

Synonyms:5-chloro-8-(furan-2-yl)-2-(3-phenylpropyl)-2H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine

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Chemical Property of 5-chloro-8-(furan-2-yl)-2-(3-phenylpropyl)-2H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine

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Technology Process of 5-chloro-8-(furan-2-yl)-2-(3-phenylpropyl)-2H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine

There total 5 articles about 5-chloro-8-(furan-2-yl)-2-(3-phenylpropyl)-2H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1357087-41-2
furan-2-carboxylic acid N'-[5-chloro-2-(3-phenyl-propyl)-2H-pyrazolo[4,3-d]pyrimidin-7-yl]-hydrazide

: 1357087-50-3
5-chloro-8-(furan-2-yl)-2-(3-phenylpropyl)-2H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine

Guidance literature:: With N,O-bis-(trimethylsilyl)-acetamide; 1,1,1,3,3,3-hexamethyl-disilazane; at 120 ℃; for 18h;
DOI:10.1016/j.bmc.2011.11.037

Reference yield:

: 1357087-11-6
4-nitro-1-(3-phenylpropyl)-1H-pyrazole-3-carboxamide

: 1357087-50-3
5-chloro-8-(furan-2-yl)-2-(3-phenylpropyl)-2H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 20 °C / 2585.81 Torr

2.1: 2 h / 200 °C / Neat (no solvent)

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / 8 h / 50 - 80 °C / Inert atmosphere

3.2: pH 7

4.1: triethylamine / 1,4-dioxane / 5 h / 80 - 90 °C

5.1: N,O-bis-(trimethylsilyl)-acetamide; 1,1,1,3,3,3-hexamethyl-disilazane / 18 h / 120 °C

With N,O-bis-(trimethylsilyl)-acetamide; palladium 10% on activated carbon; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; trichlorophosphate; In 1,4-dioxane; ethanol; 5.1: Dimroth rearrangement;
DOI:10.1016/j.bmc.2011.11.037

Reference yield:

: 1357087-18-3
4-amino-1-(3-phenylpropyl)-1H-pyrazole-3-carboxamide

: 1357087-50-3
5-chloro-8-(furan-2-yl)-2-(3-phenylpropyl)-2H-pyrazolo[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2 h / 200 °C / Neat (no solvent)

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / 8 h / 50 - 80 °C / Inert atmosphere

2.2: pH 7

3.1: triethylamine / 1,4-dioxane / 5 h / 80 - 90 °C

4.1: N,O-bis-(trimethylsilyl)-acetamide; 1,1,1,3,3,3-hexamethyl-disilazane / 18 h / 120 °C

With N,O-bis-(trimethylsilyl)-acetamide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; trichlorophosphate; In 1,4-dioxane; 4.1: Dimroth rearrangement;
DOI:10.1016/j.bmc.2011.11.037