2-[(E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-5-methyl-oct-2-enyl]-benzoic acid

Base Information

Chemical Name:2-[(E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-5-methyl-oct-2-enyl]-benzoic acid
CAS No.:314273-49-9
Molecular Formula:C₂₂H₃₆O₄Si
Molecular Weight:392.611
Hs Code.:

Synonyms:2-[(E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-5-methyl-oct-2-enyl]-benzoic acid

Suppliers and Price of 2-[(E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-5-methyl-oct-2-enyl]-benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[(E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-5-methyl-oct-2-enyl]-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[(E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-5-methyl-oct-2-enyl]-benzoic acid

There total 7 articles about 2-[(E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-5-methyl-oct-2-enyl]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 314273-48-8
2-[(E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-5-methyl-oct-2-enyl]-benzoic acid methyl ester

: 314273-49-9
2-[(E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-5-methyl-oct-2-enyl]-benzoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 16h;
DOI:10.1016/S0040-4039(00)01420-9

Reference yield:

: 2417-73-4
methyl 2-bromomethylbenzoate

: 314273-49-9
2-[(E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-5-methyl-oct-2-enyl]-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: Bu₃SnH; AIBN / benzene / 2 h / Heating

1.2: Pd₂(dba)3; TFP / 1-methyl-pyrrolidin-2-one / 24 h / 20 °C

2.1: 96 percent / LiOH / tetrahydrofuran; methanol; H₂O / 16 h / 20 °C

With lithium hydroxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; methanol; water; benzene; 1.2: Still coupling;
DOI:10.1016/S0040-4039(00)01420-9

Reference yield:

: 188926-24-1
(2R,3S)-3,5-bis{[(tert-butyl)dimethylsilyl]oxy}-2-methyl-1-pentanol

: 314273-49-9
2-[(E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-5-methyl-oct-2-enyl]-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine; DMAP / CH₂Cl₂ / 16 h / 20 °C

2.1: dimethylsulfoxide / 18 h / 20 °C

3.1: HF*pyridine; pyridine / tetrahydrofuran / 3 h / 20 °C

4.1: Bu₃SnH; AIBN / benzene / 2 h / Heating

4.2: Pd₂(dba)3; TFP / 1-methyl-pyrrolidin-2-one / 24 h / 20 °C

5.1: 96 percent / LiOH / tetrahydrofuran; methanol; H₂O / 16 h / 20 °C

With pyridine; dmap; lithium hydroxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; pyridine hydrogenfluoride; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; benzene; 4.2: Still coupling;
DOI:10.1016/S0040-4039(00)01420-9