8a-ethyl-3-(2-nitrophenyl)-1,2,3,4,6,7,8,8a-octahydro-5a-aza-acenaphthylen-5-one

Base Information

• Chemical Name: 8a-ethyl-3-(2-nitrophenyl)-1,2,3,4,6,7,8,8a-octahydro-5a-aza-acenaphthylen-5-one
• CAS No.: 119009-93-7
• Molecular Formula: C₁₉H₂₂N₂O₃
• Molecular Weight: 326.395

Synonyms:8a-ethyl-3-(2-nitrophenyl)-1,2,3,4,6,7,8,8a-octahydro-5a-aza-acenaphthylen-5-one

Chemical Property of 8a-ethyl-3-(2-nitrophenyl)-1,2,3,4,6,7,8,8a-octahydro-5a-aza-acenaphthylen-5-one

Chemical Property:

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Technology Process of 8a-ethyl-3-(2-nitrophenyl)-1,2,3,4,6,7,8,8a-octahydro-5a-aza-acenaphthylen-5-one

There total 22 articles about 8a-ethyl-3-(2-nitrophenyl)-1,2,3,4,6,7,8,8a-octahydro-5a-aza-acenaphthylen-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

9-ethyl-4-hydroxy-9-[(Z)-4-(2-nitrophenyl)but-3-enyl]-2-oxo-6,7,8,9-tetrahydro-2H-pyrido[2,1-b][1,3]thiazin-5-ylium (861219-77-4) → 8a-ethyl-3-(2-nitrophenyl)-1,2,3,4,6,7,8,8a-octahydro-5a-aza-acenaphthylen-5-one (119009-93-7)

Guidance literature:

In toluene; at 120 ℃; for 3h;

DOI:10.1021/ol0508779

Reference yield: 66.0%

9-ethyl-4-hydroxy-9-[4-(2-nitrophenyl)-but-3-enyl]-2-oxo-6,7,8,9-tetrahydro-2H-pyrido-[2,1-b][1,3]thiazin-5-ylium → 8a-ethyl-3-(2-nitrophenyl)-1,2,3,4,6,7,8,8a-octahydro-5a-aza-acenaphthylen-5-one (119009-93-7)

Guidance literature:

In toluene; at 120 ℃; for 3h; stereoselective reaction; Sealed tube;

Reference yield: 7.2%

(+/-)-4a-ethyl-3,4,4a,5,6,7-hexahydro-2H-1-pyrindine (118895-50-4,152375-27-4) + 2-nitrocinnamic acid (612-41-9) → indole (120-72-9) + 1-methyl-2-nitrobenzene (88-72-2) + 8a-ethyl-3-(2-nitrophenyl)-1,2,3,4,6,7,8,8a-octahydro-5a-aza-acenaphthylen-5-one (119009-93-7)

Guidance literature:

With ammonium o-nitrocinnamate; In 1,4-dioxane; for 90h; Heating;

DOI:10.1021/jo00290a006

upstream raw materials:

(+/-)-4a-ethyl-3,4,4a,5,6,7-hexahydro-2H-1-pyrindine

2-nitrocinnamic acid

9-ethyl-4-hydroxy-9-[(Z)-4-(2-nitrophenyl)but-3-enyl]-2-oxo-6,7,8,9-tetrahydro-2H-pyrido[2,1-b][1,3]thiazin-5-ylium

3-ethyl-3-[(Z)-4-(2-nitrophenyl)but-3-enyl]piperidine-2-thione

Downstream raw materials:

cis-(+/-)-1-(2-aminophenyl)-7a-ethyl-1,2,5,6,7,7a,8,9-octahydro-3H-cyclopentaquinolizin-3-one

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