(R)-tert-butyl (5-(4-aminophenyl)pent-4-yn-1-yl)(2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)carbamate

Base Information

Chemical Name:(R)-tert-butyl (5-(4-aminophenyl)pent-4-yn-1-yl)(2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)carbamate
CAS No.:1346424-59-6
Molecular Formula:C₃₃H₄₅N₃O₅Si
Molecular Weight:591.823
Hs Code.:

Synonyms:(R)-tert-butyl (5-(4-aminophenyl)pent-4-yn-1-yl)(2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)carbamate

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Chemical Property of (R)-tert-butyl (5-(4-aminophenyl)pent-4-yn-1-yl)(2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)carbamate

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Technology Process of (R)-tert-butyl (5-(4-aminophenyl)pent-4-yn-1-yl)(2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)carbamate

There total 6 articles about (R)-tert-butyl (5-(4-aminophenyl)pent-4-yn-1-yl)(2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1346424-58-5
(R)-N-(4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)pent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

: 1346424-59-6
(R)-tert-butyl (5-(4-aminophenyl)pent-4-yn-1-yl)(2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)carbamate

Guidance literature:: di-tert-butyl dicarbonate; (R)-N-(4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)pent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2h;

With water; potassium carbonate; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

: 126063-08-9
2,2,2-trifluoro-N-(4-iodophenyl)acetamide

: 1346424-59-6
(R)-tert-butyl (5-(4-aminophenyl)pent-4-yn-1-yl)(2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; triphenylphosphine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 4 h / 55 °C / Inert atmosphere

2.1: lithium bromide / pentan-3-one / 20 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / potassium iodide / N,N-dimethyl-formamide / 55 °C

4.1: dmap; triethylamine / dichloromethane / 2 h / 20 °C

4.2: 20 °C

With dmap; copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium bromide; bis-triphenylphosphine-palladium(II) chloride; potassium iodide; In dichloromethane; N,N-dimethyl-formamide; pentan-3-one;

Reference yield:

: 14267-92-6
1-chloro-4-pentyne

: 1346424-59-6
(R)-tert-butyl (5-(4-aminophenyl)pent-4-yn-1-yl)(2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; triphenylphosphine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 4 h / 55 °C / Inert atmosphere

2.1: lithium bromide / pentan-3-one / 20 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / potassium iodide / N,N-dimethyl-formamide / 55 °C

4.1: dmap; triethylamine / dichloromethane / 2 h / 20 °C

4.2: 20 °C

With dmap; copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium bromide; bis-triphenylphosphine-palladium(II) chloride; potassium iodide; In dichloromethane; N,N-dimethyl-formamide; pentan-3-one;