Acetic acid (2R,3R,4R,5R)-2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester

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Chemical Name:Acetic acid (2R,3R,4R,5R)-2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester
CAS No.:72687-04-8
Molecular Formula:C₁₈H₁₉N₃O₇
Molecular Weight:389.365
Hs Code.:

Synonyms:Acetic acid (2R,3R,4R,5R)-2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester

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Chemical Property of Acetic acid (2R,3R,4R,5R)-2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester

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Technology Process of Acetic acid (2R,3R,4R,5R)-2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester

There total 2 articles about Acetic acid (2R,3R,4R,5R)-2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13089-48-0
N₄-benzoylcytidine

: 72687-04-8
Acetic acid (2R,3R,4R,5R)-2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 6 h / 20 °C / Cooling with ice

1.2: 8 h / 20 °C

2.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 15 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran;

Reference yield:

: 1445-45-0
Trimethyl orthoacetate

: 13089-48-0
N₄-benzoylcytidine

: 72687-04-8
Acetic acid (2R,3R,4R,5R)-2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester

: 28224-89-7
O^3'-acetyl-N⁴-benzoyl-cytidine

Guidance literature:: for 1h; Title compound not separated from byproducts; Ambient temperature;
DOI:10.1016/S0040-4020(01)86135-4

Reference yield: 45.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 72687-04-8
Acetic acid (2R,3R,4R,5R)-2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester

: C₂₆H₃₃N₃O₈

Guidance literature:: 3,4-dihydro-2H-pyran; Acetic acid (2R,3R,4R,5R)-2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester; With toluene-4-sulfonic acid; In acetonitrile; at 20 ℃; for 8h;

With ammonia; In methanol; at 20 ℃; for 4h;