3-(2-naphthoyl)-N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-7-benzoylindolizine-1-carboxamide

Base Information

Chemical Name:3-(2-naphthoyl)-N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-7-benzoylindolizine-1-carboxamide
CAS No.:1444617-21-3
Molecular Formula:C₃₃H₃₁N₃O₅
Molecular Weight:549.626
Hs Code.:

Synonyms:3-(2-naphthoyl)-N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-7-benzoylindolizine-1-carboxamide

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Chemical Property of 3-(2-naphthoyl)-N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-7-benzoylindolizine-1-carboxamide

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Technology Process of 3-(2-naphthoyl)-N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-7-benzoylindolizine-1-carboxamide

There total 6 articles about 3-(2-naphthoyl)-N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-7-benzoylindolizine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.7%

: 929-59-9,892154-56-2
3,6-dioxa-1,8-diaminooctane

: C₃₁H₂₀N₂O₅

: 1444617-21-3
3-(2-naphthoyl)-N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-7-benzoylindolizine-1-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1111/cbdd.12119

Reference yield:

: 1454597-29-5
C₂₇H₁₇NO₄

: 1444617-21-3
3-(2-naphthoyl)-N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-7-benzoylindolizine-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 8 h / 20 °C

2: triethylamine / dichloromethane / 12 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1111/cbdd.12119

Reference yield:

: 374679-27-3
ethyl 3-(2-naphthoyl)-7-benzoylindolizine-1-carboxylate

: 1444617-21-3
3-(2-naphthoyl)-N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-7-benzoylindolizine-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / tetrahydrofuran; methanol / 5 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 8 h / 20 °C

3: triethylamine / dichloromethane / 12 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1111/cbdd.12119