3-phenylpropionic acid (4S)-2-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)ethyl ester

Base Information

Chemical Name:3-phenylpropionic acid (4S)-2-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)ethyl ester
CAS No.:327620-51-9
Molecular Formula:C₁₉H₂₈O₄
Molecular Weight:320.429
Hs Code.:

Synonyms:3-phenylpropionic acid (4S)-2-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-phenylpropionic acid (4S)-2-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)ethyl ester

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Technology Process of 3-phenylpropionic acid (4S)-2-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)ethyl ester

There total 3 articles about 3-phenylpropionic acid (4S)-2-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 327620-50-8
(4S)-2-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)ethanol

: 501-52-0
3-Phenylpropionic acid

: 327620-51-9
3-phenylpropionic acid (4S)-2-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)ethyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1021/jo005665y

Reference yield:

: 6236-09-5,2306-22-1
(S)-citramalic acid

: 327620-51-9
3-phenylpropionic acid (4S)-2-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂SO₄; MeOH

1.2: 72 percent / LAH / tetrahydrofuran

2.1: 81 percent / P₂O₅ / 15 h / 20 °C

3.1: 79 percent / DMAP; EDCI / CH₂Cl₂ / 15 h / 20 °C

With methanol; dmap; sulfuric acid; phosphorus pentoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/jo005665y

Reference yield:

: 60299-29-8
(S)-(-)-2-Methylbutane-1,2,4-triol

: 327620-51-9
3-phenylpropionic acid (4S)-2-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / P₂O₅ / 15 h / 20 °C

2: 79 percent / DMAP; EDCI / CH₂Cl₂ / 15 h / 20 °C

With dmap; phosphorus pentoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/jo005665y