(E)-3-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenal

Base Information

Chemical Name:(E)-3-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenal
CAS No.:151105-94-1
Molecular Formula:C₂₂H₁₉F₂NO
Molecular Weight:351.396
Hs Code.:

Synonyms:(E)-3-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenal

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Chemical Property of (E)-3-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenal

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Technology Process of (E)-3-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenal

There total 16 articles about (E)-3-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 151105-95-2
(Z)-3-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenal

: 151105-94-1
(E)-3-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenal

Guidance literature:: With iodine; In tetrachloromethane; for 42h; Irradiation;
DOI:10.1021/jm00075a021

Reference yield: 47.0%

: 3-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenol

: 151105-95-2
(Z)-3-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenal

: 151105-94-1
(E)-3-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenal

Guidance literature:: With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm00075a021

Reference yield:

: 115672-63-4
1-(4-fluorophenyl)-5-methyl-2-(2-pyridyl)-1,4-hexanedione

: 151105-94-1
(E)-3-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenal

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / ammonium acetate, AcOH / Heating

2: 1.) NaH / 1.) DMF, 10 min, 2.) DMF, 20 deg C, 1 h

3: DIBAL-H / toluene / -65 - -5 °C

4: 20 percent / MnO₂ / CH₂Cl₂ / 1 h / 20 °C

5: 81 percent / I₂ / CCl₄ / 42 h / Irradiation

With ammonium acetate; manganese(IV) oxide; iodine; sodium hydride; diisobutylaluminium hydride; acetic acid; In tetrachloromethane; dichloromethane; toluene;
DOI:10.1021/jm00075a021