4-[2-[(1-(phenyl)ethyl)amino]ethyl]-1-[(4-fluorophenyl)methyl]piperidine

Base Information

Chemical Name:4-[2-[(1-(phenyl)ethyl)amino]ethyl]-1-[(4-fluorophenyl)methyl]piperidine
CAS No.:333363-94-3
Molecular Formula:C₂₂H₂₉FN₂
Molecular Weight:340.484
Hs Code.:

Synonyms:4-[2-[(1-(phenyl)ethyl)amino]ethyl]-1-[(4-fluorophenyl)methyl]piperidine

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Chemical Property of 4-[2-[(1-(phenyl)ethyl)amino]ethyl]-1-[(4-fluorophenyl)methyl]piperidine

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Technology Process of 4-[2-[(1-(phenyl)ethyl)amino]ethyl]-1-[(4-fluorophenyl)methyl]piperidine

There total 3 articles about 4-[2-[(1-(phenyl)ethyl)amino]ethyl]-1-[(4-fluorophenyl)methyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 333363-93-2
4-[[(1-phenylethyl)aminocarbonyl]methyl]-1-[(4-fluorophenyl)methyl]piperidine

: 333363-94-3
4-[2-[(1-(phenyl)ethyl)amino]ethyl]-1-[(4-fluorophenyl)methyl]piperidine

Guidance literature:: With borane; In tetrahydrofuran; for 6h; Heating;
DOI:10.1021/jm000311k

Reference yield:

: 185434-40-6
1-[(4-fluorophenyl)methyl]-4-[(ethoxycarbonyl)methyl]piperidine

: 333363-94-3
4-[2-[(1-(phenyl)ethyl)amino]ethyl]-1-[(4-fluorophenyl)methyl]piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: CF₃CO₂H; aq. HCl / 2 h / Heating

2.1: EDCI; HOBT / CH₂Cl₂ / 1 h / 20 °C

2.2: CH₂Cl₂ / 20 °C

3.1: 95 percent / BH₃ / tetrahydrofuran / 6 h / Heating

With hydrogenchloride; borane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm000311k

Reference yield:

: 1027554-05-7
[1-(4-Fluoro-benzyl)-piperidin-4-yl]-acetic acid

: 333363-94-3
4-[2-[(1-(phenyl)ethyl)amino]ethyl]-1-[(4-fluorophenyl)methyl]piperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: EDCI; HOBT / CH₂Cl₂ / 1 h / 20 °C

1.2: CH₂Cl₂ / 20 °C

2.1: 95 percent / BH₃ / tetrahydrofuran / 6 h / Heating

With borane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm000311k