(2R,3R,4S)-3-Acetylamino-4-[2,3-bis(tert-butoxycarbonyl)guanidino]-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester 2-(2,3,4,5,6-pentafluorophenyl)ester

Base Information

Chemical Name:(2R,3R,4S)-3-Acetylamino-4-[2,3-bis(tert-butoxycarbonyl)guanidino]-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester 2-(2,3,4,5,6-pentafluorophenyl)ester
CAS No.:185382-08-5
Molecular Formula:C₃₉H₃₉F₅N₄O₁₀
Molecular Weight:818.751
Hs Code.:

(2R,3R,4S)-3-Acetylamino-4-[2,3-bis(tert-butoxycarbonyl)guanidino]-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester 2-(2,3,4,5,6-pentafluorophenyl)ester

Synonyms:(2R,3R,4S)-3-Acetylamino-4-[2,3-bis(tert-butoxycarbonyl)guanidino]-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester 2-(2,3,4,5,6-pentafluorophenyl)ester

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Chemical Property of (2R,3R,4S)-3-Acetylamino-4-[2,3-bis(tert-butoxycarbonyl)guanidino]-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester 2-(2,3,4,5,6-pentafluorophenyl)ester

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Technology Process of (2R,3R,4S)-3-Acetylamino-4-[2,3-bis(tert-butoxycarbonyl)guanidino]-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester 2-(2,3,4,5,6-pentafluorophenyl)ester

There total 7 articles about (2R,3R,4S)-3-Acetylamino-4-[2,3-bis(tert-butoxycarbonyl)guanidino]-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester 2-(2,3,4,5,6-pentafluorophenyl)ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 185382-04-1
(2R,3R,4S)-3-Acetylamino-4-[2,3-bis(tert-butoxycarbonyl)-guanidino]-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester

: 14533-84-7
pentafluorophenyl trifloroacetate

: 185382-08-5
(2R,3R,4S)-3-Acetylamino-4-[2,3-bis(tert-butoxycarbonyl)guanidino]-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester 2-(2,3,4,5,6-pentafluorophenyl)ester

Guidance literature:: With pyridine; hydrogenchloride; sodium hydrogencarbonate; In N-methyl-acetamide; ethyl acetate;

Reference yield:

: 14533-84-7
pentafluorophenyl trifloroacetate

: 185382-04-1
(2R,3R,4S)-3-(acetylamino)-4-(2,3-bis(tert-butoxycarbonyl)guanidino)-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester

: 185382-08-5
(2R,3R,4S)-3-(acetylamino)-4-(2,3-bis(tert-butoxycarbonyl)guanidino)-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester 2-(2,3,4,5,6-pentafluorophenyl) ester

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; at 23 ℃; for 3h;

Reference yield:

: 130525-62-1
5-acetamido-4-amino-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid

: 185382-08-5
(2R,3R,4S)-3-(acetylamino)-4-(2,3-bis(tert-butoxycarbonyl)guanidino)-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester 2-(2,3,4,5,6-pentafluorophenyl) ester

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / methanol / 18 h / 23 °C

2: aq. HCl / CH₂Cl₂ / 18 h / 23 °C

3: aq. NaIO₄ / methanol / 1.5 h / 23 °C

4: NaClO₂, aq. KH₂PO₄, cyclohexene / 2-methyl-propan-2-ol / 2 h / 23 °C

5: pyridine / dimethylformamide / 3 h / 23 °C

With pyridine; hydrogenchloride; sodium chlorite; sodium periodate; potassium dihydrogenphosphate; triethylamine; cyclohexene; In methanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;