5-(3-methyl-1,2,4-oxadiazol-5-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4-(1H,3H)pyrimidinedione

Base Information

• Chemical Name: 5-(3-methyl-1,2,4-oxadiazol-5-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4-(1H,3H)pyrimidinedione
• CAS No.: 1138450-11-9
• Molecular Formula: C₂₂H₂₂F₃N₅O₃
• Molecular Weight: 461.444

Synonyms:5-(3-methyl-1,2,4-oxadiazol-5-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4-(1H,3H)pyrimidinedione

Chemical Property of 5-(3-methyl-1,2,4-oxadiazol-5-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4-(1H,3H)pyrimidinedione

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Technology Process of 5-(3-methyl-1,2,4-oxadiazol-5-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4-(1H,3H)pyrimidinedione

There total 1 articles about 5-(3-methyl-1,2,4-oxadiazol-5-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4-(1H,3H)pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,5R)-3-(3-chloropropyl)-1-[4-(trif luoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane (863679-55-4) + 6-hydroxy-5-(3-methyl-1,2,4-oxadiazol-5-yl)-2(1H)-pyrimidinone (1138450-62-0) → 5-(3-methyl-1,2,4-oxadiazol-5-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4-(1H,3H)pyrimidinedione (1138450-11-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; sodium iodide; In dimethyl sulfoxide; at 80 - 120 ℃;

Reference yield:

5-(3-methyl-1,2,4-oxadiazol-5-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4-(1H,3H)pyrimidinedione (1138450-11-9) → 5-(3-methyl-1,2,4-oxadiazol-5-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4-(1H,3H)pyrimidinedione hydrochloride (1138450-12-0)

Guidance literature:

With hydrogenchloride; In diethyl ether; dichloromethane;

upstream raw materials:

(1S,5R)-3-(3-chloropropyl)-1-[4-(trif luoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane

6-hydroxy-5-(3-methyl-1,2,4-oxadiazol-5-yl)-2(1H)-pyrimidinone

Downstream raw materials:

5-(3-methyl-1,2,4-oxadiazol-5-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4-(1H,3H)pyrimidinedione hydrochloride

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