4-(chloromethyl)-7-[ (4-fluorobenzyl)oxy]-2H-chromen-2-one

Base Information

• Chemical Name: 4-(chloromethyl)-7-[ (4-fluorobenzyl)oxy]-2H-chromen-2-one
• CAS No.: 1270046-45-1
• Molecular Formula: C₁₇H₁₂ClFO₃
• Molecular Weight: 318.732
• Mol file: 1270046-45-1.mol

Synonyms:4-(chloromethyl)-7-[ (4-fluorobenzyl)oxy]-2H-chromen-2-one

Chemical Property of 4-(chloromethyl)-7-[ (4-fluorobenzyl)oxy]-2H-chromen-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-(chloromethyl)-7-[ (4-fluorobenzyl)oxy]-2H-chromen-2-one

There total 2 articles about 4-(chloromethyl)-7-[ (4-fluorobenzyl)oxy]-2H-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-chloromethyl-7-hydroxycoumarin (25392-41-0) + 4-Fluorobenzyl bromide (459-46-1) → 4-(chloromethyl)-7-[ (4-fluorobenzyl)oxy]-2H-chromen-2-one (1270046-45-1)

Guidance literature:

With potassium carbonate; In ethanol; for 3h; Reflux;

DOI:10.1021/jm101120u

Reference yield:

recorcinol (108-46-3) → 4-(chloromethyl)-7-[ (4-fluorobenzyl)oxy]-2H-chromen-2-one (1270046-45-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 24 h / -5 °C

2: potassium carbonate / acetone / 4 h / Reflux

With sulfuric acid; potassium carbonate; In acetone; 1: |Pechmann Condensation;

DOI:10.1016/j.bioorg.2020.104564

Reference yield: 66.0%

1H-imidazole (288-32-4) + 4-(chloromethyl)-7-[ (4-fluorobenzyl)oxy]-2H-chromen-2-one (1270046-45-1) → 7-[(4-fluorobenzyl)oxy]-4-(1H-imidazol-1-ylmethyl)-2H-chromen-2-one (1270046-05-3)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; Reflux;

DOI:10.1021/jm101120u

upstream raw materials:

4-chloromethyl-7-hydroxycoumarin

4-Fluorobenzyl bromide

recorcinol

Downstream raw materials:

7-[(4-fluorobenzyl)oxy]-4-(1H-imidazol-1-ylmethyl)-2H-chromen-2-one