2-benzoyl-5-chlorodihydrocinnamide

Base Information

• Chemical Name: 2-benzoyl-5-chlorodihydrocinnamide
• CAS No.: 139437-30-2
• Molecular Formula: C₁₆H₁₄ClNO₂
• Molecular Weight: 287.746
• Mol file: 139437-30-2.mol

Synonyms:2-benzoyl-5-chlorodihydrocinnamide

Chemical Property of 2-benzoyl-5-chlorodihydrocinnamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzoyl-5-chlorodihydrocinnamide

There total 5 articles about 2-benzoyl-5-chlorodihydrocinnamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-benzoyl-5-chlorocinnamide (139437-29-9) → 2-benzoyl-5-chlorodihydrocinnamide (139437-30-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In 1,4-dioxane;

DOI:10.1016/0040-4039(92)88040-C

Reference yield:

water (7732-18-5) + 2-benzoyl-5-chlorocinnamide (139437-29-9) + 2-propenamide (79-06-1,12624-24-7,25038-45-3,27754-57-0,33338-03-3,39387-77-4,68247-81-4,9082-06-8,79079-15-5) → 2-benzoyl-5-chlorodihydrocinnamide (139437-30-2)

Guidance literature:

With sodium acetate; palladium-carbon; palladium diacetate; In 1,4-dioxane; benzophenone; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

4-chloro-2-iodobenzoic acid (13421-13-1) → 2-benzoyl-5-chlorodihydrocinnamide (139437-30-2)

Guidance literature:

Multi-step reaction with 4 steps

1: PCl₅

2: AlCl₃ / 1,2-dichloro-ethane

3: 84 percent / NaOAc / Pd(OAc)2 / dimethylformamide; H₂O / 16 h / 125 °C

4: 89 percent / H₂ / 10percent Pd/C / dioxane

With aluminium trichloride; phosphorus pentachloride; hydrogen; sodium acetate; palladium diacetate; palladium on activated charcoal; In 1,4-dioxane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(92)88040-C

upstream raw materials:

2-benzoyl-5-chlorocinnamide

4-chloro-2-iodobenzoic acid

2-iodo-4-chlorobenzoyl chloride

(4-chloro-2-iodophenyl)(phenyl)methanone

Downstream raw materials:

7-Chloro-1-phenyl-4,5-dihydro-benzo[c]azepin-3-one

7-chloro-1-phenyl-1,2,4,5-tetrahydro-2(3H)-benzazepin-3-one